Prolonged jaundice in newborns is associated with low antioxidant capacity in breast milk

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dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridDogan, Derya Gumus/0000-0003-1587-9639
dc.authoridTatli, Mustafa Mansur/0000-0003-2767-3734
dc.authorwosidTatli, Mansur M/E-6160-2016
dc.authorwosidUras, Nurdan/AAR-5383-2020
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.authorwosidTONBUL, ALPARSLAN/N-1115-2015
dc.authorwosidDogan, Derya Gumus/ABG-9945-2020
dc.contributor.authorUras, Nurdan
dc.contributor.authorTonbul, Alpaslan
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorDogan, Derya G.
dc.contributor.authorErel, Ozcan
dc.contributor.authorTatli, Mustafa M.
dc.date.accessioned2024-08-04T20:32:32Z
dc.date.available2024-08-04T20:32:32Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn breastfeeding newborns who are otherwise healthy, the mechanism of prolonged jaundice remains unclear. The aim of this study was to investigate relations between prolonged jaundice and oxidative parameters in breast milk. Full-term, otherwise healthy newborns with jaundice lasting more than 2 weeks were enrolled prospectively in the study. As a control group, newborns in the same age group but without prolonged jaundice were selected. All newborns in the study were exclusively breastfed. In the newborns with prolonged jaundice, investigations of the etiology of the jaundice included complete blood count, peripheral blood smear, blood typing, direct Coombs test, measurement of serum levels of total and direct bilirubin, tests for liver and thyroid function (TSH, free T4, total T4), urine culture and measurement of urine reducing substances, and determination of glucose 6 phosphate dehydrogenase enzyme levels. Breast milk was collected from the mothers of the newborns in both groups. The antioxidant status of the breast milk was assessed via determination of total antioxidant capacity (TAG). Oxidative stress was also assessed in breast milk by measurement of total oxidation status (TOS) and calculation of the oxidative stress index (OSI). The prolonged jaundice group differed significantly from the control group in terms of mean TAG and OSI (p < 0.001), but not in terms of TOS. In conclusion, in the breast milk of mothers of newborns with prolonged jaundice, oxidative stress was found to be increased, and protective antioxidant capacity was found to be decreased.en_US
dc.identifier.doi10.3109/00365513.2010.506556
dc.identifier.endpage437en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue6en_US
dc.identifier.pmid20681927en_US
dc.identifier.scopus2-s2.0-77956641455en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage433en_US
dc.identifier.urihttps://doi.org/10.3109/00365513.2010.506556
dc.identifier.urihttps://hdl.handle.net/11616/95128
dc.identifier.volume70en_US
dc.identifier.wosWOS:000282914400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal of Clinical & Laboratory Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeonatal jaundiceen_US
dc.subjecthuman milken_US
dc.subjectantioxidantsen_US
dc.titleProlonged jaundice in newborns is associated with low antioxidant capacity in breast milken_US
dc.typeArticleen_US

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