Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children

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dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.contributor.authorTabel, Y.
dc.contributor.authorBerdeli, A.
dc.contributor.authorMir, S.
dc.date.accessioned2024-08-04T20:30:38Z
dc.date.available2024-08-04T20:30:38Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate Arg753Gln allele polymorphisms of toll-like receptor-2 (TLR2) gene distribution, allele frequency in urinary tract infection (UTI) and genotype-phenotype association of TLR2 gene in children with UTI. The polymorphism was investigated in 124 children with UTI (22 boys and 102 girls; mean age 5.81 +/- 3.47 years) with direct DNA sequencing-based method. TLR2 gene Arg753Gln allele frequency was higher in the patient group when compared with control group (OR 3.14, 95%CI 1.53-6.44, P < 0.001). The frequency of the Arg753Gln allele was significantly higher in gram-positive group than in gram-negative group (OR 7.64, 95%CI 2.80-20.81, P < 0.001). The frequency of UTI was found significantly higher in the Arg753Gln allele carriers of TLR2 gene than the non-carriers (OR 4.94, 95%CI 1.09-22.33, P < 0.05). Similarly, the incidence of asymptomatic UTI was also found significantly higher in the group carrying Arg753Gln allele (OR 3.73, 95%Cl 1.54-9.04, P < 0.05). As a result, we suggest that TLR2 gene could be the predisposing factor for urinary tract infection. Additionally, we observed that subjects carrying the TLR2 Arg753Gln allele had higher risk of urinary tract infection with gram-positive pathogens, history of more than two attacks of UTI and asymptomatic UTI.en_US
dc.identifier.doi10.1111/j.1744-313X.2007.00709.x
dc.identifier.endpage405en_US
dc.identifier.issn1744-3121
dc.identifier.issn1744-313X
dc.identifier.issue6en_US
dc.identifier.pmid18001294en_US
dc.identifier.scopus2-s2.0-36248986638en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.1111/j.1744-313X.2007.00709.x
dc.identifier.urihttps://hdl.handle.net/11616/94401
dc.identifier.volume34en_US
dc.identifier.wosWOS:000250940400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Immunogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToll-Like Receptorsen_US
dc.subjectCutting Edgeen_US
dc.subjectImmune-Responseen_US
dc.subjectLipopolysaccharideen_US
dc.subjectRecognitionen_US
dc.subjectActivationen_US
dc.subjectCellsen_US
dc.subjectMiceen_US
dc.titleAssociation of TLR2 gene Arg753Gln polymorphism with urinary tract infection in childrenen_US
dc.typeArticleen_US

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