Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

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dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridGenç, Metin Fikret/0000-0002-6244-0517
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidGenç, Metin Fikret/ABI-2169-2020
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.contributor.authorKamisli, Suat
dc.contributor.authorBasaran, Cenk
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorOztanir, Mustafa Namik
dc.contributor.authorGul, Mehmet
dc.contributor.authorSatilmis, Basri
dc.contributor.authorUyumlu, Ayse Burcin
dc.date.accessioned2024-08-04T20:45:50Z
dc.date.available2024-08-04T20:45:50Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods: Global cerebral ischemia was induced for five minutes in adult male Wistar Albino rats via the 4-vessel occlusion method. Intravenous administration of 1 mg/kg RS100642 following reperfusion for 30 min (RS100642 group) was compared with a sham treatment group (ischemia group) and nonischemized group (control) histologically based on morphology and caspase-3 immunohistochemistry, and biochemically based both on measurement of oxidative stress including malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and on assessment of apoptosis including caspase-3 and -8 activities and tumor necrosis factor alpha (TNF-alpha) levels at the end of 6 h. Results: While the RS100642 group had significantly lower MDA levels and higher SOD activities than the sham treatment group (p < 0.05), GPx and CAT activities of the RS100642 and sham treatment groups were similar (p > 0.05) and significantly lower than those of the controls (p < 0.05). Necrosis and caspase-3 activity and immunoreactivity in the RS100642 group were significantly lower than those in the sham treatment group (p < 0.05), while there was no significant difference between groups regarding caspase-8 and TNF-alpha (p > 0.05). Conclusions: Na+ channel blockade by RS100642 has remarkable neuroprotective effects following global brain ischemia/reperfusion damage. Further research is required to determine the optimum dose and time of administration.en_US
dc.description.sponsorshipScientific Research Coordination Department of Inonu Universityen_US
dc.description.sponsorshipThe authors would like to thank Roche Pharm. Co., USA for providing RS100642. This project was supported by a grant from the Scientific Research Coordination Department of Inonu University.en_US
dc.identifier.doi10.5114/aoms.2017.72550
dc.identifier.endpage474en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue2en_US
dc.identifier.pmid30899300en_US
dc.identifier.scopus2-s2.0-85062735430en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2017.72550
dc.identifier.urihttps://hdl.handle.net/11616/98719
dc.identifier.volume15en_US
dc.identifier.wosWOS:000460168400021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbrain injuryen_US
dc.subjectglobal cerebral ischemiaen_US
dc.subjectsodium channelsen_US
dc.subjectneuroprotectionen_US
dc.titleNeuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injuryen_US
dc.typeArticleen_US

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