The effect of esmolol on the QTc interval during induction of anaesthesia in patients with coronary artery disease

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dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.contributor.authorErdil, F.
dc.contributor.authorDemirbilek, S.
dc.contributor.authorBegec, Z.
dc.contributor.authorOzturk, E.
dc.contributor.authorBut, A.
dc.contributor.authorOzcan Ersoy, M.
dc.date.accessioned2024-08-04T20:31:08Z
dc.date.available2024-08-04T20:31:08Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate whether esmolol has an effect on QT interval during induction of anaesthesia using etomidate and fentanyl in patients with known coronary artery disease. Sixty patients were prospectively randomised to either a control group or the esmolol group. Esmolol was administered as a bolus 1 mg.kg(-1), followed by a continuous infusion at 250 mu g.kg(-1)min(-1). All patients received etomidate 0.3 mg.kg(-1) and fentanyl 15 mu g.kg(-1). The ECG was recorded prior to induction of anaesthesia (T0), 5 min following the start of drug infusions (T1), 1 min following etomidate (T2), 3 min following vecuronium (T3), 30 s (T4), 2 min (T5) and 4 min (T6) after intubation. In the esmolol group, QTc interval was significantly shorter at T1, T2 and T4 compared to the control group (p < 0.05). In conclusion, QTc interval increased following tracheal intubation during induction of anaesthesia using etomidate and fentanyl. An infusion of Esmolol attenuated the QTc interval prolongation associated with tracheal intubation.en_US
dc.identifier.doi10.1111/j.1365-2044.2008.05754.x
dc.identifier.endpage250en_US
dc.identifier.issn0003-2409
dc.identifier.issn1365-2044
dc.identifier.issue3en_US
dc.identifier.pmid19302635en_US
dc.identifier.scopus2-s2.0-61749092496en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage246en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2044.2008.05754.x
dc.identifier.urihttps://hdl.handle.net/11616/94759
dc.identifier.volume64en_US
dc.identifier.wosWOS:000263242800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofAnaesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTracheal Intubationen_US
dc.subjectHemodynamic-Responsesen_US
dc.subjectHeart-Rateen_US
dc.subjectDispersionen_US
dc.subjectCombinationen_US
dc.subjectAlfentanilen_US
dc.subjectPressureen_US
dc.subjectPropofolen_US
dc.subjectFentanylen_US
dc.subjectTrialen_US
dc.titleThe effect of esmolol on the QTc interval during induction of anaesthesia in patients with coronary artery diseaseen_US
dc.typeArticleen_US

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