Relationship between serum homocysteine levels and structural-functional carotid arterialabnormalities in inactive Behcet's disease
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
VIA MEDICA, UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
Background: Behcet's disease (BD) is a chronic autoimmune disorder with symptoms manifesting from an underlying vasculitis. Since the disease activity is correlated with characteristic vascular endothelial dysfunction, BD places individuals at increased risk of cardiovascular diseases, such as atherosclerosis. Hyperhomocysteinaemia is an independent risk factor for arteriosclerotic vascular diseases.
Aim: This study was designed to investigate how plasma homocysteine (Hcy) affects the structural and functional properties of the carotid artery in humans.
Methods: Sixty-eight BD patients with subclinical atherosclerosis and 40 healthy controls underwent carotid sonography and Doppler ultrasound to measure carotid artery intima-media thickness (C-IMT) and carotid stiffness and distensibility (indicating elasticity). Total Hcy level was determined by enzyme-linked immunosorbent assay. For analysis, the BD patients were sub-grouped according to hyperhomocysteinaemia (>15 mu mol/L).
Results: The patients with BD were found to have increased C-IMT and beta stiffness and decreased distensibility. In addition, hyperhomocysteinaemia was significantly correlated with these detrimental changes in the carotid artery, possibly raising the risk of these patients developing atherosclerosis.
Conclusions: These findings suggest a potential mechanism of atherosclerosis in BD and highlight the processes that future research should focus on to address identification and prophylactic treatment of BD patients at risk of cardiovascular disease.
Açıklama
Anahtar Kelimeler
Intıma-Medıa Thıckness, Cardıovascular Involvement, Endothelıal Dysfunctıon, Dıstensıbılıty, Stıffness;, Atherosclerosıs, Markers
Kaynak
Kardıologıa polska
WoS Q Değeri
Scopus Q Değeri
Cilt
76
Sayı
2
Künye
Yağmur, J. Açıkgöz, N. Cansel, M. Karıncaoğlu, Y. Ermiş, N. Pekdemir, H. Arslan, AK. (2018). Relationship between serum homocysteine levels and structural-functional carotid arterialabnormalities in inactive Behcet's disease. Cilt:76 Sayı:2, 413-417 ss.
