Relationship between serum homocysteine levels and structural-functional carotid arterialabnormalities in inactive Behcet's disease

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dc.contributor.authorYağmur, Jülide
dc.contributor.authorAçıkgöz, Nusret
dc.contributor.authorCansel, Mehmet
dc.contributor.authorKarıncaoğlu, Yelda
dc.contributor.authorErmiş, Necip
dc.contributor.authorPekdemir, Hasan
dc.contributor.authorArslan, A. Kadir
dc.date.accessioned2019-07-24T05:58:53Z
dc.date.available2019-07-24T05:58:53Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Behcet's disease (BD) is a chronic autoimmune disorder with symptoms manifesting from an underlying vasculitis. Since the disease activity is correlated with characteristic vascular endothelial dysfunction, BD places individuals at increased risk of cardiovascular diseases, such as atherosclerosis. Hyperhomocysteinaemia is an independent risk factor for arteriosclerotic vascular diseases. Aim: This study was designed to investigate how plasma homocysteine (Hcy) affects the structural and functional properties of the carotid artery in humans. Methods: Sixty-eight BD patients with subclinical atherosclerosis and 40 healthy controls underwent carotid sonography and Doppler ultrasound to measure carotid artery intima-media thickness (C-IMT) and carotid stiffness and distensibility (indicating elasticity). Total Hcy level was determined by enzyme-linked immunosorbent assay. For analysis, the BD patients were sub-grouped according to hyperhomocysteinaemia (>15 mu mol/L). Results: The patients with BD were found to have increased C-IMT and beta stiffness and decreased distensibility. In addition, hyperhomocysteinaemia was significantly correlated with these detrimental changes in the carotid artery, possibly raising the risk of these patients developing atherosclerosis. Conclusions: These findings suggest a potential mechanism of atherosclerosis in BD and highlight the processes that future research should focus on to address identification and prophylactic treatment of BD patients at risk of cardiovascular disease.en_US
dc.identifier.citationYağmur, J. Açıkgöz, N. Cansel, M. Karıncaoğlu, Y. Ermiş, N. Pekdemir, H. Arslan, AK. (2018). Relationship between serum homocysteine levels and structural-functional carotid arterialabnormalities in inactive Behcet's disease. Cilt:76 Sayı:2, 413-417 ss.en_US
dc.identifier.doi10.5603/KP.a2017.0227en_US
dc.identifier.endpage417en_US
dc.identifier.issue2en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://hdl.handle.net/11616/12884
dc.identifier.volume76en_US
dc.language.isoenen_US
dc.publisherVIA MEDICA, UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLANDen_US
dc.relation.ispartofKardıologıa polskaen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectIntıma-Medıa Thıcknessen_US
dc.subjectCardıovascular Involvementen_US
dc.subjectEndothelıal Dysfunctıonen_US
dc.subjectDıstensıbılıtyen_US
dc.subjectStıffness;en_US
dc.subjectAtherosclerosısen_US
dc.subjectMarkersen_US
dc.titleRelationship between serum homocysteine levels and structural-functional carotid arterialabnormalities in inactive Behcet's diseaseen_US
dc.typeArticleen_US

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