Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer

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dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridOzdemirel, Huseyin Ozgur/0000-0002-3284-5185
dc.authorwosidAcar, Ceren/M-2926-2019
dc.authorwosidErdem Tuncdemir, Beril/JGD-1957-2023
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.contributor.authorAcar, Ceren
dc.contributor.authorCelik, Sibel Kucukyildirim
dc.contributor.authorOzdemirel, H. Ozgur
dc.contributor.authorTuncdemir, Beril Erdem
dc.contributor.authorAlan, Saadet
dc.contributor.authorMergen, Hatice
dc.date.accessioned2024-08-04T20:54:28Z
dc.date.available2024-08-04T20:54:28Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe human intestine is a habitat for microorganisms and, recently, the composition of the intestinal microbiota has been correlated with the etiology of diseases such as inflammations, sores, and tumors. Although many studies have been conducted to understand the composition of that microbiota, expanding these studies to more samples and different backgrounds will improve our knowledge. In this work, we showed the colon microbiota composition and diversity of healthy subjects, patients with inflammatory bowel disease (IBD), and colon cancer by metagenomic sequencing. Our results indicated that the relative abundance of prokaryotic and eukaryotic microbes differs between the healthy vs. tumor biopsies, tumor vs. IBD biopsies, and fresh vs. paraffin-embedded tumor biopsies. Fusobacterium, Escherichia-Shigella, and Streptococcus genera were relatively abundant in fresh tumor biopsies, while Pseudomonas was significantly elevated in IBD biopsies. Additionally, another opportunist pathogen Malasseziales was revealed as the most abundant fungal clade in IBD biopsies, especially in ulcerative colitis. We also found that, while the Basidiomycota:Ascomycota ratio was slightly lower in tumor biopsies compared to biopsies from healthy subjects, there was a significant increase in IBD biopsies. Our work will contribute to the known diversity of prokaryotic and eukaryotic microbes in the colon biopsies in patients with IBD and colon cancer.en_US
dc.description.sponsorshipInonu University Research Fund [FCD-2020-2065]en_US
dc.description.sponsorshipAcknowledgementsWe thank Dr. E. Hakan Alan and Dr. Zulfikar Polat. This work was supported by a grant from Inonu University Research Fund (FCD-2020-2065).en_US
dc.identifier.doi10.1007/s12223-023-01072-w
dc.identifier.endpage345en_US
dc.identifier.issn0015-5632
dc.identifier.issn1874-9356
dc.identifier.issue2en_US
dc.identifier.pmid37344611en_US
dc.identifier.scopus2-s2.0-85162958401en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1007/s12223-023-01072-w
dc.identifier.urihttps://hdl.handle.net/11616/101427
dc.identifier.volume69en_US
dc.identifier.wosWOS:001012929500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFolia Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMycobiomeen_US
dc.subjectMetabarcodingen_US
dc.subject16SrRNAen_US
dc.subject18SrRNAen_US
dc.subjectUlcerative colitisen_US
dc.subjectCrohn's diseaseen_US
dc.titleComposition of the colon microbiota in the individuals with inflammatory bowel disease and colon canceren_US
dc.typeArticleen_US

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