Early regular versus late selective poractant treatment in preterm infants born between 25 and 30 gestational weeks: a prospective randomized multicenter study

Basit Öğe Kaydı
dc.authoridÖzer, Esra/0000-0003-2634-7136
dc.authoridGursoy, Tugba/0000-0002-6084-4067
dc.authoridOGUZ, SUNA SERIFE/0000-0002-1870-0983
dc.authoridBas, Ahmet Yagmur/0000-0002-1329-2167
dc.authoridERDEVE, OMER/0000-0002-3193-0812
dc.authorwosidÖzer, Esra/AFD-5742-2022
dc.authorwosidGursoy, Tugba/AGO-5295-2022
dc.authorwosidDemirel, Nihal/ABI-5267-2020
dc.authorwosidOGUZ, SUNA SERIFE/GWZ-7382-2022
dc.authorwosidUras, Nurdan/AAR-5383-2020
dc.authorwosidBas, Ahmet Yagmur/ABI-5260-2020
dc.authorwosidZoglu, Aysegul/HJP-7031-2023
dc.contributor.authorDilmen, Ugur
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorAksoy, Hatice Tatar
dc.contributor.authorUras, Nurdan
dc.contributor.authorDemirel, Nihal
dc.contributor.authorKirimi, Ercan
dc.contributor.authorErdeve, Omer
dc.date.accessioned2024-08-04T20:38:01Z
dc.date.available2024-08-04T20:38:01Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Surfactant treatment in the early hours of life significantly decreases the rates of death and air leak, and increases survival without bronchopulmonary dysplasia (BPD) in preterm infants. We aimed to compare the impact of early surfactant (ES) administration to late selective (LS) treatment on neonatal outcomes in preterm infants. Methods: All preterm infants between 25 and 30 wks gestational age and who were not entubated in the delivery room and did not have any major congenital malformation or perinatal asphyxia were randomized to ES treatment (200 mg/kg Curosurf (R) administration in 1 hour after birth) or LS treatment (200 mg/kg Curosurf (R) administration in the first 6 h of life if needed). The patients were treated by nasal continuous positive airway pressure (nCPAP) treatment regardless of the surfactant requirement. Outcomes were the necessity of mechanical ventilation, nCPAP duration, the oxygen requirement duration, the rates of BPD, retinopathy of prematurity (ROP) and mortality, and the assesment of the following situations; (pneumothorax, patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), and intraventricular hemorrhage (IVH) >= grade III). Results: Among 159 infants enrolled in the study, 79 were randomized to ES and 80 to LS treatment groups. Thirty-five patients (44%) in the LS treatment group needed surfactant administration. Necessity of second dose surfactant administration was 8.9% in the ES treatment group. Although necessity of mechanical ventilation, nCPAP duration, oxygen need duration, rates of PDA, NEC, BPD, ROP stage >3 and mortality did not show a significant difference between groups, the ES treatment group had lower rates of pneumothorax and IVH >= grade III when compared to the LS treatment group. Conclusions: ES treatment decreases IVH (>= grade III) and pneumothorax rates but does not have any effect on BPD when compared to LS.en_US
dc.identifier.doi10.3109/14767058.2013.818120
dc.identifier.endpage415en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue4en_US
dc.identifier.pmid23795582en_US
dc.identifier.scopus2-s2.0-84892685774en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.818120
dc.identifier.urihttps://hdl.handle.net/11616/96327
dc.identifier.volume27en_US
dc.identifier.wosWOS:000330068000021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectpneumothoraxen_US
dc.subjectporactanten_US
dc.subjectpretermen_US
dc.subjectsurfactanten_US
dc.titleEarly regular versus late selective poractant treatment in preterm infants born between 25 and 30 gestational weeks: a prospective randomized multicenter studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu