Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoriddurak, mehmet akif akif/0000-0003-0827-2708
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosiddurak, mehmet akif akif/ABI-1169-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorDurak, M. A.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorPolat, A.
dc.contributor.authorVardi, N.
dc.contributor.authorEkici, K.
dc.contributor.authorUcar, M.
dc.contributor.authorOzhan, O.
dc.date.accessioned2024-08-04T20:42:56Z
dc.date.available2024-08-04T20:42:56Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the protective and therapeutic effects of molsidomine (MOL) in a rat model of whole brain radiotherapy (RT). Forty female rats were divided into five groups of eight: group 1, control; group 2, 15 Gy single dose RT (RT); group 3, 4 mg/kg MOL treated for 5 days (MOL); group 4, 4 mg/kg MOL for 5 days, 10 days after RT treatment (RT + MOL); group 5, 4 mg/kg MOL treatment for 5 days before RT treatment and for 5 days after RT treatment (MOL + RT). All rats were sacrificed on day 16. Neurodegenerative changes in the brain and tissue levels of oxidants and antioxidants were evaluated. The oxidative parameters were increased and antioxidant status was decreased in group RT compared to groups MOL + RT and RT + MOL. Histopathological examination showed that treatment with MOL after RT application and treatment with MOL before RT treatment decreased neuronal degeneration. No difference in neuronal appearance was found between groups RT + MOL and MOL + RT. MOL treatment protected the nervous system of rats and may be a treatment option for preventing RT induced neural injury.en_US
dc.identifier.doi10.1080/10520295.2016.1271454
dc.identifier.endpage77en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid28166419en_US
dc.identifier.scopus2-s2.0-85011632720en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2016.1271454
dc.identifier.urihttps://hdl.handle.net/11616/97683
dc.identifier.volume92en_US
dc.identifier.wosWOS:000395756300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmolsidomineen_US
dc.subjectneural damageen_US
dc.subjectoxidative stressen_US
dc.subjectradiotherapyen_US
dc.subjectraten_US
dc.titleProtective and therapeutic effects of molsidomine on radiation induced neural injury in ratsen_US
dc.typeArticleen_US

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