Changing pH of Bronchoalveolar Lavage Fluid in Patients Undergoing Extracorporeal Circulation
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bilimsel Tip Publishing House
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Since bronchoalveolar lavage (BAL) fluid can give a dynamic impression of what is present or developing in situ on the air exchange surface, we worked with BAL fluid to solve the etiopathogenesis of pulmonary complications due to cardiopulmonary bypass (CPB). Forty BAL fluid samples were obtained in 10 patients, undergoing coronary artery bypass grafting (CABG) surgery. Samples were obtained at the following time periods: 1. preoperatively; 2. at the end of the first hour after anesthetic induction; 3. at the conclusion of 30 min. of crossclamp on CPB; 4. 20 h after CPB. Neither calcium nor potassium ions were detectable in any sample. Mean pH of preoperative bronchoalveolar lavage fluid was 6.361 (SD +/- 3,55.10(-2)) and the other mean pH values were 6.375 (SD +/- 0.44), 6.567 (SD +/- 0.165), 6.470 (SD +/- 9,29.10(-2)), respectively. There was not any significant change between the first two steps (p=0.241). Likewise, the change between the third and fourth samples was not statistically significant (p=0.074). However, the change between the second and third studies was statistically significant (p=0.005). And also, the change between preoperative and final studies was statistically significant (p=0.007). The mean recoveries of lavage fluids was about 64% in the first samplings, 75% in the second, 73.4% in the third, and 56% in the fourth. This study reveals that CPB alters one of the main favorable conditions of ecosystem in bronchoalveolar space, namely the pH. Besides, excessive mucous secretion in an involved lung due to CPB which limits making BAL is the reason for atelectasis. As reported in the previous studies, since bronchoalveolar pH changes affect substances like surfactant, this study will set the baseline for further studies.
Açıklama
Anahtar Kelimeler
heart surgery, cardiopulmonary bypass, bronchoalveolar lavage, pH, atelectasis, extracorporeal circulation
Kaynak
Turkish Thoracic Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
6
Sayı
1
