An antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in rats
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Human&experimental toxicology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tumor necrosis factor (TNF)-a antibodies have been shown to reduce liver damage in different models. We
investigated the effects of infliximab (a TNF-a antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity
in rats. Group 1 (n ¼ 8) was the control group. In group 2 (n ¼ 8), the TAA group, the rats received
300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n ¼ 8), the TAA þ Infliximab (INF) group,
infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and
was maintained for 4 consecutive days. In group 4 (n ¼ 8), the INF group, the rats received only ip infliximab
(5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive
substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine
transaminase (ALT), TNF-a, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the
TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except
AST were not significantly different between TAA and TAA þ INF. In conclusion, our results suggest that oxidative
stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative
liver damage.
Açıklama
Anahtar Kelimeler
Infliximab, Tumor necrosis factor-a, Thioacetamide, Oxidative stress, Liver
Kaynak
Human&experimental toxicology
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
7
Künye
Demirel, U. Harputoğlu, M. M. M. Seçkin, Y. Çıralık, H. Temel, İ. Özyalın, F. Otlu, B. Yılmaz, B. Dinçtürk, M. S. Aladağ, H. (2011). An antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in rats. Human & experimental toxicology. 30(7) 560–566.
