An antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in rats

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dc.authorid101949en_US
dc.contributor.authorDemirel, Ulvi
dc.contributor.authorHarputoğlu, Muhsin Murat Muhip
dc.contributor.authorSeçkin, Yüksel
dc.contributor.authorÇıralık, Harun
dc.contributor.authorTemel, İsmail
dc.contributor.authorÖzyalın, Fatma
dc.contributor.authorOtlu, Barış
dc.contributor.authorYılmaz, Bilgiç
dc.contributor.authorDinçtürk, Mehmet Sarp
dc.contributor.authorAladağ, Hülya
dc.date.accessioned2017-07-15T07:23:43Z
dc.date.available2017-07-15T07:23:43Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTumor necrosis factor (TNF)-a antibodies have been shown to reduce liver damage in different models. We investigated the effects of infliximab (a TNF-a antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity in rats. Group 1 (n ¼ 8) was the control group. In group 2 (n ¼ 8), the TAA group, the rats received 300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n ¼ 8), the TAA þ Infliximab (INF) group, infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and was maintained for 4 consecutive days. In group 4 (n ¼ 8), the INF group, the rats received only ip infliximab (5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine transaminase (ALT), TNF-a, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except AST were not significantly different between TAA and TAA þ INF. In conclusion, our results suggest that oxidative stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative liver damage.en_US
dc.identifier.citationDemirel, U. Harputoğlu, M. M. M. Seçkin, Y. Çıralık, H. Temel, İ. Özyalın, F. Otlu, B. Yılmaz, B. Dinçtürk, M. S. Aladağ, H. (2011). An antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in rats. Human & experimental toxicology. 30(7) 560–566.en_US
dc.identifier.endpage566en_US
dc.identifier.issn0960-3271
dc.identifier.issue7en_US
dc.identifier.startpage560en_US
dc.identifier.urihttps://hdl.handle.net/11616/7382
dc.identifier.volume30en_US
dc.language.isoenen_US
dc.publisherHuman&experimental toxicologyen_US
dc.relation.ispartofHuman&experimental toxicologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfliximaben_US
dc.subjectTumor necrosis factor-aen_US
dc.subjectThioacetamideen_US
dc.subjectOxidative stressen_US
dc.subjectLiveren_US
dc.titleAn antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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