Analysis of pediatric thrombotic patients in Turkey

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dc.authoridKEMAHLI, Sabri/0000-0002-5573-1703
dc.authoridErtem, Mehmet/0000-0002-8173-7885
dc.authorwosidKEMAHLI, Sabri/ADX-1134-2022
dc.authorwosidÖren, Hale/ACI-5453-2022
dc.contributor.authorÖren, H
dc.contributor.authorDevecioglu, Ö
dc.contributor.authorErrem, M
dc.contributor.authorVergin, C
dc.contributor.authorKavakli, K
dc.contributor.authorMeral, A
dc.contributor.authorCanatan, D
dc.date.accessioned2024-08-04T20:30:58Z
dc.date.available2024-08-04T20:30:58Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study analyzes the data of thrombotic children who were followed up in different pediatric referral centers of Turkey, to obtain more general data on the diagnosis, risk factors, management, and outcome of thrombosis in Turkish children. A simple two-page questionnaire was distributed among contact people from each center to standardize data collection. Thirteen pediatric referral centers responded to the invitation and the total number of cases was 271. All children were diagnosed with thromboembolic disease between January 1995 and October 2001. Median age at time of first thrombotic event was 7.0 years. Of the children 4% of the cases were neonates, 12% were infants less than 1 year old, and 17% were adolescents. Thromboembolic event was mostly located in the cerebral vascular system (32%), deep venous system of the limbs, femoral and iliac veins (24%), portal veins (10%), and intracardiac region (9%). Acquired risk factors were present in 86% of the children. Infection was the most common underlying risk factor. Inherited risk factors were present in 30% of the children. FVL was the most common inherited risk factor. Acquired and inherited risk factors were present simultaneously in 19% of the patients. Eleven children had a history of familial thrombosis. Due to the local treatment preferences, the treatment of the children varied greatly. Outcome of the 142 patients (52%) was reported: 88 (62%) patients had complete resolution, 47 (33%) had complications, 12 (9%) had recurrent thrombosis, and 34 (24%) died. Three children (2.1%) died as a direct consequence of their thromboembolic disease. The significant morbidity and mortality found in this study supports the need for multicentric prospective clinical trials to obtain more generalizable data on management and outcome of thrombosis in Turkish children.en_US
dc.identifier.doi10.1080/08880010490500935
dc.identifier.endpage583en_US
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue7en_US
dc.identifier.pmid15626013en_US
dc.identifier.scopus2-s2.0-5044234800en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org/10.1080/08880010490500935
dc.identifier.urihttps://hdl.handle.net/11616/94639
dc.identifier.volume21en_US
dc.identifier.wosWOS:000223843200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPediatric Hematology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildhooden_US
dc.subjectthromboembolismen_US
dc.subjectthrombosisen_US
dc.titleAnalysis of pediatric thrombotic patients in Turkeyen_US
dc.typeArticleen_US

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