PEPPSI type Pd(II)NHC complexes bearing chloro-/fluorobenzyl group: Synthesis, characterization, crystal structures, ?-glycosidase and acetylcholinesterase inhibitory properties

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.contributor.authorBal, Selma
dc.contributor.authorDemirci, Ozlem
dc.contributor.authorSen, Betul
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAktas, Aydin
dc.contributor.authorGok, Yetkin
dc.contributor.authorAygun, Muhittin
dc.date.accessioned2024-08-04T20:49:16Z
dc.date.available2024-08-04T20:49:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis work reported the synthesis of a new PEPPSI (Pyridine Enhanced Precatalyst Preparation, Stabilization and Initiation) type Pd(II)N-heterocyclic carbene (NHC) complexes bearing halo-benzyl (4-florobenzyl and 2-chloro-4-florobenzyl) group. These new complexes were synthesized from the florobenzyl / chlorofluorobenzyl substituted benzimidazolium salts, PdCl2 and pyridine. Characterizations of all the synthesized complexes were done using elemental analysis, H-1 NMR, C-13 NMR and FT-IR spectroscopy techniques. The molecular and crystal structures of the new PEPPSI type Pd(II)NHC complexes were determined by single-crystal X-ray diffraction method. X-ray studies show that molecular structures of three complexes comprise a palladium(II) atom with a slightly distorted square-planar coordination environment. These synthesized salts were found to be effective inhibitors for the alpha-glycosidase, and acetylcholinesterase (AChE) enzyme with K-i values in the range of 27.36 +/- 5.06-124.88 +/- 18.05 mu M for alpha-glycosidase, and 0.78 +/- 0.11-4.34 +/- 1.02 mu M for AChE, respectively. The significant group of drugs currently utilized for the therapy of Alzheimer's disease (AD) is acetylcholinesterase/cholinesterase inhibitor compounds. The first cholinesterase inhibitor licensed for symptomatic therapy of AD was tacrine. Inhibition acts of alpha-glycosidase enzyme by inhibitors tend to slow the breakdown and release of sugar molecules into the bloodstream and can be utilized as therapeutic factors in the therapy of obesity and diabetes. (C) 2021 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund [FYL-2020-2279]; Kahramanmaras Sutcu Imam University Research Fund [2019/6-23M]; Dokuz Eylul University [2010.KB.FEN.13]en_US
dc.description.sponsorshipThis study was financially supported by Inonu University Research Fund (Project Code: FYL-2020-2279) and Kahramanmaras Sutcu Imam University Research Fund (Project Code: 2019/6-23M). The authors thank the Inonu University Faculty of Science Department of Chemistry for the spectroscopy and elemental analysis characterization of compounds. The authors thank the Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1016/j.poly.2021.115060
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85100424870en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2021.115060
dc.identifier.urihttps://hdl.handle.net/11616/99751
dc.identifier.volume198en_US
dc.identifier.wosWOS:000637967200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPd(II)NHC complexesen_US
dc.subjectCrystal structuresen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectalpha-Glycosidaseen_US
dc.titlePEPPSI type Pd(II)NHC complexes bearing chloro-/fluorobenzyl group: Synthesis, characterization, crystal structures, ?-glycosidase and acetylcholinesterase inhibitory propertiesen_US
dc.typeArticleen_US

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