The effects of montelukast against amikacin-induced acute renal damage

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dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridSoysal, Handan/0000-0001-7550-6362
dc.authoridÖner, Zülal/0000-0003-0459-1015
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.authorwosidSoysal, Handan/AAL-4660-2020
dc.authorwosidÖner, Zülal/T-2515-2019
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorKose, E.
dc.contributor.authorBeytur, A.
dc.contributor.authorDogan, Z.
dc.contributor.authorEkincioglu, Z.
dc.contributor.authorVardi, N.
dc.contributor.authorCinar, K.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-08-04T20:35:57Z
dc.date.available2024-08-04T20:35:57Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Objectives: The therapeutic and protective effects of montelukast against amikacin-induced acute renal damage were investigated. Material and Methods: 35 Wistar albino female rats were divided into 5 groups as follows: Group I: Control; Group II: Control+montelukast; Group III: Amikacin; Group IV: Amikacin+montelukast; Group V: Montelukast+amikacin. At the end of the experiment, the kidney tissues and the blood of rats were collected. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined from kidney tissues. Blood urea nitrogen (BUN), creatinine (Cr), TNF-alpha, and IL-1 beta levels were assessed in the serum. In addition the kidney tissues were examined histologically. Results and Discussion: The MDA, MPO, BUN, and Cr levels of group III significantly increased when compared to groups I and II. These parameters of group IV decreased when compared to group III. In addition, GSH levels significantly increased when compared to the first three groups. MDA, BUN and Cr levels of group V did not reach significant level in comparison with the control group. The most significant histological damage was observed in the group III followed by the groups IV and V. Immunohistochemically, group III showed a significantly increased apoptotic staining. In group IV, it was observed that montelukast treatment reduced the expression of apoptotic cells. Conclusions: Montelukast treatment after amikacin injection could reduce the amikacin-induced kidney damage.en_US
dc.description.sponsorshipInonu University [2010/57]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific Research Fund of Inonu University (2010/57).en_US
dc.identifier.endpage511en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid22696878en_US
dc.identifier.scopus2-s2.0-84862650090en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://hdl.handle.net/11616/95693
dc.identifier.volume16en_US
dc.identifier.wosWOS:000303783200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmikacinen_US
dc.subjectMontelukasten_US
dc.subjectKidney Renal functionen_US
dc.subjectHistologyen_US
dc.titleThe effects of montelukast against amikacin-induced acute renal damageen_US
dc.typeArticleen_US

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