Thermosonication Processing of Purple Onion Juice (Allium cepa L.): Anticancer, Antibacterial, Antihypertensive, and Antidiabetic Effects

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dc.authoridyıkmış, seydi/0000-0001-8694-0658
dc.authoridTokatlı Demirok, Nazan/0000-0003-1936-9337
dc.authoridTürkol, Melikenur/0000-0001-7354-9529
dc.authoridDOGUER, CAGLAR/0000-0003-0059-1819
dc.authorwosidyıkmış, seydi/V-5890-2017
dc.authorwosidTokatlı Demirok, Nazan/ABA-3007-2020
dc.authorwosidTürkol, Melikenur/ISV-0542-2023
dc.contributor.authorYikmis, Seydi
dc.contributor.authorErdal, Berna
dc.contributor.authorDoguer, Caglar
dc.contributor.authorLevent, Okan
dc.contributor.authorTurkol, Melikenur
dc.contributor.authorDemirok, Nazan Tokatli
dc.date.accessioned2024-08-04T20:55:54Z
dc.date.available2024-08-04T20:55:54Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOnion (Allium cepa L.) juice is an important product used in gastronomy and food formulations. The first objective of this study was to optimize the content of bioactive compounds in purple onion juice (POJ) after the thermosonication process using response surface methodology (RSM) and artificial neural network (ANN) application models. Second, the anticancer, antibacterial, antihypertensive, and antidiabetic effects of POJ obtained after thermal pasteurization (P-POJ) or thermosonication (TS-POJ) were investigated after obtaining the ANN and RSM analysis reports. The optimization process for TS-POJ was carried out at 44 degrees C, for 13 min, with a 68% amplitude. The findings demonstrated that the angiotensin-converting enzyme (ACE) inhibition level was greater in TS-POJ samples than in the untreated control (C-POJ) sample (p > 0.05). C-POJ, TS-POJ, and P-POJ exhibited the inhibition of cell proliferation in vitro in a dose-dependent manner in lung (A549), cervical (HeLa), and colon cancer cells following 24 h incubation. Thermosonication or thermal pasteurization did not markedly affect the cell proliferation of the examined cancer cells compared to the untreated control group. While no antibacterial effect was observed with low concentrations of samples, they showed an antibacterial effect at pure concentrations (100%). The thermosonication treatment for processing purple onion juice was successful in this study's results.en_US
dc.description.sponsorshipTekirdag Namik Kemal University Scientific Research Coordination Unit [NKUBAP.48.GA.21.335]en_US
dc.description.sponsorshipPart of the data obtained from this study was supported by the study conducted by the Tekirdag Namik Kemal University Scientific Research Coordination Unit with Project Number NKUBAP.48.GA.21.335.en_US
dc.identifier.doi10.3390/pr12030517
dc.identifier.issn2227-9717
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85189134665en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/pr12030517
dc.identifier.urihttps://hdl.handle.net/11616/101910
dc.identifier.volume12en_US
dc.identifier.wosWOS:001193435300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofProcessesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpurple onionen_US
dc.subjectthermosonicationen_US
dc.subjectartificial neural networken_US
dc.subjectanticanceren_US
dc.subjectantibacterialen_US
dc.titleThermosonication Processing of Purple Onion Juice (Allium cepa L.): Anticancer, Antibacterial, Antihypertensive, and Antidiabetic Effectsen_US
dc.typeArticleen_US

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