Changes in antibody titers against Chlamydia pneumoniae after coronary angioplasty

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dc.authoridİmadoğlu Yetkin, Gülay/0000-0002-6115-3583
dc.authoridMert, Ali/0000-0001-8945-2385
dc.authorwosidİmadoğlu Yetkin, Gülay/AAO-2547-2020
dc.contributor.authorYetkin, G
dc.contributor.authorYetkin, E
dc.contributor.authorAksoy, Y
dc.contributor.authorGurbuz, OA
dc.contributor.authorMert, A
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The potential role of common infectious agents in the pathogenesis and progression of atherosclerosis has been studied increasingly over the last decade. The evidence for Chlamydia pneumoniae as a potential causative agent is strong and is based on the findings of numerous sero-epidemiological studies, examination of atheromatous plaque specimens, in vitro animal models. We performed a prospective study in percutaneous transluminal coronary angioplasty (PTCA) patients to investigate whether the angioplasty procedure influenced the specific humoral immune response reaction against C. pneumoniae antigens. Methods: We studied 76 patients who successfully underwent PTCA for de novo lesions. Blood samples were drawn immediately before PTCA and 1 month after PTCA. IgG and IgA antibodies against C. pneumoniae (strain CDC/CY&-029) were determined by an in-house developed enzyme inummoassay. Results: At the time of angioplasty 75% and 34% of the patients had seropositive antibodies to elementary bodies (EBs) of classes IgG and IgA, respectively. Mean titers of IgG antibodies before and I month after PTCA were 46 +/- 31 and 50 +/- 28 relative units (RU/ml) (P > 0.05). One month after PTCA, 97% and 34% of the patients had seropositive antibodies to EBs of classes IgG and IgA, respectively. We divided our patients into two groups on the basis of IgG seropositivity (group I: Chlamydia antibody IgG seronegative patients, group II: Chlamydia antibody IgG seropositive) before PTCA. Significant increase in the antibody titers of IgG (12 5 vs. 40 18, P < 0.001) and IgA (0.6 +/- 0.33 vs. 1.15 +/- 0.83, P = 0.007) was observed in group I patients 1 month after PTCA and 88% of them gained IgG seropositivity. There were no significant changes in IgG and IgA antibody levels in group II after PTCA. Conclusion: We have demonstrated a statistically significant rise in C. pneumoniae antibodies (especially IgG) induced by PTCA in patients previously seronegative. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2003.04.045
dc.identifier.endpage297en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue2-3en_US
dc.identifier.pmid15193835en_US
dc.identifier.scopus2-s2.0-2942601465en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2003.04.045
dc.identifier.urihttps://hdl.handle.net/11616/94198
dc.identifier.volume95en_US
dc.identifier.wosWOS:000222169900028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatheroselerosisen_US
dc.subjectChlamydia pneumoniaeen_US
dc.subjectcoronary angioplastyen_US
dc.titleChanges in antibody titers against Chlamydia pneumoniae after coronary angioplastyen_US
dc.typeArticleen_US

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