Bevacizumab plus irinotecan in recurrent or progressive malign glioma: a multicenter study of the Anatolian Society of Medical Oncology (ASMO)

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dc.authoridOzturk, Banu/0000-0003-0290-8787
dc.authoridharputluoglu, hakan/0000-0001-8537-5941
dc.authoridbenekli, mustafa/0000-0003-3184-4946
dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authoridKaplan, Muhammet Ali/0000-0003-0882-0524
dc.authoridDEMIRCI, UMUT/0000-0002-4833-6721
dc.authorwosidOzturk, Banu/AAD-4358-2019
dc.authorwosidharputluoglu, hakan/ABI-6451-2020
dc.authorwosidTufan, Gulnihal/HIZ-9729-2022
dc.authorwosidbenekli, mustafa/AAE-4555-2020
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidUNEK, ILKAY/P-9566-2019
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.contributor.authorDemirci, Umut
dc.contributor.authorTufan, Gulnihal
dc.contributor.authorAktas, Bilge
dc.contributor.authorBalakan, Ozan
dc.contributor.authorAlacacioglu, Ahmet
dc.contributor.authorDane, Faysal
dc.contributor.authorEngin, Huseyin
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe overall prognosis for recurrent malignant glioma (MG) is extremely poor, and treatment options are limited. We evaluated our multicenter retrospective experience for patients with recurrent MG administering bevacizumab and irinotecan in combination therapy. A total of 115 patients with grade IV glial tumor (n = 93) and grade III glial tumor (n = 22) were retrospectively evaluated at 14 centers in Turkey. Primary objectives of the study were to evaluate the efficacy and toxicity of the bevacizumab and irinotecan as salvage treatment based on response to therapy, progression-free survival (PFS), 6 months of PFS, overall survival (OS), and 6 months of OS (OS6). Bevacizumab and irinotecan were performed as second line (79.1 %) and third line treatment (20.9 %). Median chemotherapy cycle was 6 (range 1-37), and median follow-up was 6 months (range 1-36 months). Objective response rate was 39.1 %. Six-month PFS and OS6 were 46.3 % and 67.5 %, respectively. Median PFS was 6 months (95 % CI 2.5-9.5) and 6 months (95 % CI 4.9-7.1) in the grade III and IV groups, respectively (p = 0.773). Median OS was 9 months (95 % CI 7.1-10.9) and 8 months (95 % CI 6.6-9.4) in the grade III and IV groups, respectively (p = 0.450). Serious toxicities were observed in 7.8 % of patients. Treatment-related toxic death was observed in 3 patients. There was no treatment related to central nervous system hemorrhage or other serious hemorrhages. Present study results were consistent with previous studies. In addition, we detected similar outcomes in grade III and IV glial tumors.en_US
dc.identifier.doi10.1007/s00432-013-1390-8
dc.identifier.endpage835en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue5en_US
dc.identifier.pmid23400732en_US
dc.identifier.scopus2-s2.0-84876290291en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage829en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-013-1390-8
dc.identifier.urihttps://hdl.handle.net/11616/96008
dc.identifier.volume139en_US
dc.identifier.wosWOS:000317649100012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBevacizumaben_US
dc.subjectIrinotecanen_US
dc.subjectRecurrent diseaseen_US
dc.subjectMalignant gliomaen_US
dc.titleBevacizumab plus irinotecan in recurrent or progressive malign glioma: a multicenter study of the Anatolian Society of Medical Oncology (ASMO)en_US
dc.typeArticleen_US

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