The diagnostic efficacy of some ischemic markers (urotensin II and urotensin II related peptide) in early diagnosis of intestinal ischemia in experimentally increased intraabdominal pressure in rats

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dc.contributor.authorBozan, Mehmet Bugra
dc.contributor.authorAyten, Refik
dc.contributor.authorBulbuller, Nurullah
dc.contributor.authorCamci, Cemalettin
dc.contributor.authorAygen, Erhan
dc.contributor.authorİlhan, Necip
dc.contributor.authorOzercan, Hanfi Ibrahim
dc.contributor.authorAzak Bozan, Ayse
dc.contributor.authorAksu, Ali
dc.contributor.authorKutluer, Nizamettin
dc.date.accessioned2022-03-02T16:40:55Z
dc.date.available2022-03-02T16:40:55Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The purpose of this experimental study is evaluating the relation between plasma urotensin-II (U-II) and urotensin-II related peptide (URP) levels with intestinal ischemia caused by elevated intraabdominal pressure.Material-Methods: Wistar albino rats weighing 200–250 grams used.Group-1: Laparatomized group without abdominal pressure elevation in sixty minutes under general anesthesia.Group-2: Ten mmHg elevated intraabdominal pressure group in sixty minutes under general anesthesia.Group-3: Fifteen mmHg elevated intraabdominal pressure group in sixty minutes under general anesthesia.Group-4: Twenty mmHg elevated intraabdominal pressure group in sixty minutes under general anesthesia.After sacrifing, in general anesthesia blood and tissue samples were collected. Hematoxilen and eosyn stained tissue samples were examined under light microscope.Results: Plasma U-II levels changes insignificant in group 2 and 3 but in group-4 was changed significantly compared with the control group(respectevely p=0,609; p=0.848; p=0.04). Plasma URP levels changed significantly in all groups compared with the control group (p-values were p=0.018; p=0.018 and p=0.04 respectively).Conclusion: U-II levels could not be a useful parameter for the early diagnosis of the intestinal ischemic damage caused byintraabdominal pressure(IAP), because it is found in all vascular structures. On the other hand, plasma URP levels would be used for the early diagnosis of the intestinal ischemia. Because of the limitations of our study, we believe that our results should be confirmed with clinical studies.Keywords: Intrabdominal hypertension; intestinal ischemia; urotensin-ii; urotensin-ii related peptid; abdominal compartment syndrome.en_US
dc.identifier.citationBugra Bozan, M., Ayten, R., Bulbuller, N., Camci, C., Aygen, E., İlhan, N., Hanfi Ozercan, I., Azak Bozan, A., Aksu, A., & Kutluer, N. (2021). The diagnostic efficacy of some ischemic markers (urotensin II and urotensin II related peptide) in early diagnosis of intestinal ischemia in experimentally increased intraabdominal pressure in rats . Annals of Medical Researchen_US
dc.identifier.urihttps://hdl.handle.net/11616/54189
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe diagnostic efficacy of some ischemic markers (urotensin II and urotensin II related peptide) in early diagnosis of intestinal ischemia in experimentally increased intraabdominal pressure in ratsen_US
dc.typeArticleen_US

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