Efficacy of colchicine treatment in COVID-19 patients: A case-control study
Küçük Resim Yok
Tarih
2022
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Various clinical studies have been conducted on many alternative options in treating COVID-19 since the beginning of the pandemic process. This study aimed to investigate the effectiveness of colchicine treatment in patients hospitalized in clinical wards due to COVID-19. Methods: The study was retrospectively planned between October 2020 and October 2021. A total of 110 cases who received colchicine + standard treatment (favipiravir + corticosteroid + anticoagulant + symptomatic treatment) were included in the study group. The control group included randomly selected 220 patients who received only standard treatment. All cases' demographic characteristics, features of antibiotic and corticosteroid treatment, comorbidities, and clinical courses were recorded. Patients who received treatment for less than three days due to COVID-19, patients aged >95 years and <18 years, and those transferred to the clinical wards from the intensive care unit were excluded from the study. The groups were compared regarding treatment failure, including the number of intensive care unit admissions and mortality due to COVID-19 infection. Results: While the mean age was 59.4 years in the study group, it was 65.0 years in the control group (p=0.001). The most common coexisting disease was hypertension (63%). There were significant differences between the groups in the proportions of antibiotic use (p=0.002) and high-dose corticosteroid use (p=0.004). The values of white blood cell count (p=0.003), urea (p=0.029), D-dimer (p=0.021), creatine kinase-myocardial band (p=0.003) and troponin (p<0.001) were statistically different. There was no difference in terms of intensive care unit admission (p=0.174), the mortality rate (p=1.000), and treatment failure (p=0.505). Conclusions: According to the results of our study, colchicine treatment does not affect the prognosis of COVID-19 patients. There is a need for prospective studies investigating the role of colchicine treatment in COVID-19 infections.
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Anahtar Kelimeler
Kaynak
Archives of Clinical and Experimental Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
1
