Investigation of the effect of milrinone on renal damage in an experimental non-heart beating donormodel

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dc.contributor.authorBatcıoğlu, Kadir
dc.contributor.authorUyumlu, Burçin A.
dc.contributor.authorKaradağ, Mehmet
dc.date.accessioned2019-07-18T08:02:24Z
dc.date.available2019-07-18T08:02:24Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: In our study, it was aimed to investigate the preventive effect of milrinone on renal damage in experimental controlled non-heart-beating donors (NHBDs) model. Materials and Methods: Sixteen rats randomly divided into 2 groups, 8 rats in each were used. Group 1 was control, group 2 was milrinone group. Group 1 rats received 1.25ml 0.09% NaCl intraperitoneally equivalent to the milrinone diluted volume. Group 2 rats were administered intraperitoneally with 0.5mg/kg of milrinone 2hours before cardiac arrest. After the cardiac arrest, left nephrectomy was applied to the rats. Malondialdehyde, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) activities, Caspase-3 (apoptotic index) and histopathological evaluation were performed in the tissues. Results: In the milrinone group, the total injury score was significantly lower relative to the control group (p = 0.001). Caspase-3 staining was moderately strong in the control group but weaker in the milrinone group. Apoptotic index was significantly lower in the milrinone group compared to the control group (p = 0.001). In comparison between groups, SOD and GPx in the milrinone group was significantly higher than the control group (p = 0.008, p = 0.006). Conclusions: Milrinone has been shown to be effective in the prevention of tissue damage due to oxidative stress and inflammatory process in the renal of warm ischemia in the experimental NHBDs model and in protecting the renal. Milrinone increases antioxidant activity while reducing apoptosis. Systemic administration of milrinone prior to cardiac arrest may be beneficial. Administration of milrinone to the recipient in the perioperative period may contribute to donor function.en_US
dc.identifier.citationBatcıoğlu, K. Uyumlu, BA. Karadağ, M. (2018). Investigation of the effect of milrinone on renal damage in an experimental non-heart beating donormodel. Cilt:31 Sayı:5, 402-411 ss.en_US
dc.identifier.doi10.1080/08941939.2017.1343880en_US
dc.identifier.endpage411en_US
dc.identifier.issue5en_US
dc.identifier.startpage402en_US
dc.identifier.urihttps://hdl.handle.net/11616/12729
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAen_US
dc.relation.ispartofJOURNAL OF INVESTIGATIVE SURGERYen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemıa-Reperfusıon Injuryen_US
dc.subjectTumor-Necrosıs-Factoren_US
dc.subjectKıdney-Transplantatıonen_US
dc.subjectOxıdatıve Damageen_US
dc.subjectWarm Ischemıaen_US
dc.subjectLıver-Damageen_US
dc.subjectApoptosısen_US
dc.subjectRatsen_US
dc.subjectAttenuatıonen_US
dc.subjectGraftsen_US
dc.titleInvestigation of the effect of milrinone on renal damage in an experimental non-heart beating donormodelen_US
dc.typeArticleen_US

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