Microbial chondroitin sulfate in experimental knee osteoarthritis model investigation of chondroprotective effect

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridGeckil, Hikmet/0000-0003-0070-0691
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorSevimli, R.
dc.contributor.authorErenler, A. S.
dc.contributor.authorKarabulut, A. B.
dc.contributor.authorAkpolat, N.
dc.contributor.authorGeckil, H.
dc.date.accessioned2024-08-04T20:50:41Z
dc.date.available2024-08-04T20:50:41Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Chondroitin sulfate (CS) is a glycosaminoglycan with proven anti-inflammatory, anti-apoptotic, anti-oxidant properties. CS increases type II collagen and proteoglycan synthesis in human joint chondrocytes. CS can reduce the production of pro-inflammatory mediators and proteases to improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Due to these characteristics, it is a natural compound that is considered to be Symptomatic Slow-Acting Drugs for Osteoarthritis (SYSADOA). Microbial chondroitin sulfate (MCS) was produced from two different bacterial sources using biotechnological methods by our team. In this study, we aimed to apply microbially produced CS and bovine- derived commercial CS forms to rabbit knees with osteoarthritis experimentally and to evaluate the results. MATERIALS AND METHODS: In this study, a cruciate ligament cutting model was applied to 40 New Zealand rabbits to induce experimental osteoarthritis. Four weeks after the surgical procedure, rabbits were divided into 4 groups as control, animal-derived MCS, E coli- derived MCS and PaJC-derived MCS group. The standard rabbit diet was fed to the control group, and the other groups were additionally fed 17 mg/kg/day CS/MCS for 12 weeks. The rabbits were sacrificed at the 12th week after surgery and the preparations obtained were evaluated histopathologically. RESULTS: As a result, it was observed that regeneration tissue was statistically significant in histopathological cartilage tissue compared to the control group of CS developed from different sources given to rabbits with osteoarthritis. It was determined that among the CS groups produced from different sources, the group with the highest chondroprotective effect was MCS originating from E.coli. CONCLUSIONS: This vegan product (MCS), which we obtained as a result of our study, was produced by our team from a microbial source. According to our analysis, it has the potential to be an effective alternative therapy agent in the treatment of osteoarthritis.en_US
dc.description.sponsorshipTUBITAK [1001 (215S-861)]en_US
dc.description.sponsorshipThis study was supported by TUBITAK 1001 (215S-861).en_US
dc.identifier.endpage5411en_US
dc.identifier.issn1128-3602
dc.identifier.issue17en_US
dc.identifier.pmid34533814en_US
dc.identifier.scopus2-s2.0-85114775300en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5402en_US
dc.identifier.urihttps://hdl.handle.net/11616/100201
dc.identifier.volume25en_US
dc.identifier.wosWOS:000695653800012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChondroitin sulfateen_US
dc.subjectMicrobial chondrotin sulfateen_US
dc.subjectOsteoarthritisen_US
dc.subjectCondroprotectiveen_US
dc.titleMicrobial chondroitin sulfate in experimental knee osteoarthritis model investigation of chondroprotective effecten_US
dc.typeArticleen_US

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