Silver (I)-N-heterocyclic carbene complexes: Synthesis and characterization, biological evaluation of Anti-Cholinesterase, anti-alpha-amylase, anti-lipase, and antibacterial activities, and molecular docking study

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dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridKarci, Huseyin/0000-0002-5709-1623
dc.authoridKHIRI-MERIBOUT, Naima/0000-0001-8906-0250
dc.authoridMOKRANI, El Hassen/0000-0002-2725-2940
dc.authoridbensouici, chawki/0000-0003-4612-4642
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidKarci, Huseyin/AAC-3985-2022
dc.authorwosidbensouici, chawki/H-3088-2018
dc.contributor.authorSandeli, Abd El-Krim
dc.contributor.authorKhiri-Meribout, Naima
dc.contributor.authorBenzerka, Saida
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorDundar, Muhammed
dc.contributor.authorKarci, Huseyin
dc.contributor.authorBensouici, Chawki
dc.date.accessioned2024-08-04T20:50:18Z
dc.date.available2024-08-04T20:50:18Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of novel silver(I)-N-heterocyclic carbene complexes have been prepared and fully characterized by spectroscopic methods and X-ray crystallographic analyses. The biological capacity of the synthesized compounds was evaluated in vitro for their anti-microbial, anti-cholinesterase, anti-lipase, anti-diabetic activities in search of potent inhibitors compound. All compounds were tested against two types of fungi and three bacterias. The results proved that most compounds indicated moderate to excellent activity against all types of bacteria and fungi except compound 2f that didn't show any antibacterial activity. The synthesized compound's capacity to inhibit the enzymes AChE, BChE, Lipase, and alpha-amylase were evaluated. The results showed that silver(I)-NHC complexes 3a-f are effective against all types of enzymes. The highest activity was reported toward AChE, BChE, and alpha-amylase enzymes, and at a lower rate against Lipase enzyme compared to the references drug. In contrast, benzimidazolium salts 2a-f, which showed significant inhibitory activity against AChE and BChE enzymes, while all salts were not active against both Lipase and alpha-amylase enzymes. Molecular docking simulations using AutoDock, have been performed of the new compounds as a representative set of our molecules into AChE and BChE enzymes for lead optimization of the binding interaction template of the most active inhibitors docked into the active site of their relevant AChE and BChE enzymes inhibitors.en_US
dc.description.sponsorshipScientific Research Projects Unit of Ondokuz Mays University [PYO.FEN.1906.19.001]; Inodnu Universityen_US
dc.description.sponsorshipThe authors greatly acknowledge financial support from the Inodnu University Research Fund of this work. X-ray analyses were supported by the Scientific Research Projects Unit of Ondokuz Mays University (Project No: PYO.FEN.1906.19.001) .en_US
dc.identifier.doi10.1016/j.ica.2021.120486
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85107784538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2021.120486
dc.identifier.urihttps://hdl.handle.net/11616/99982
dc.identifier.volume525en_US
dc.identifier.wosWOS:000675727400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrystal-Structuresen_US
dc.subjectStructural-Characterizationen_US
dc.subjectRecognitionen_US
dc.subjectGold(I)en_US
dc.titleSilver (I)-N-heterocyclic carbene complexes: Synthesis and characterization, biological evaluation of Anti-Cholinesterase, anti-alpha-amylase, anti-lipase, and antibacterial activities, and molecular docking studyen_US
dc.typeArticleen_US

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