Investigation of the effect of watercress via nuclear factor- E2-related factor-2 pathway on 7,12-dimethylbenz[a] anthracene-induced oxidative damage in rat liver

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dc.contributor.authorAtay, Kübra
dc.contributor.authorUyumlu, Ayşe Burçin
dc.contributor.authorSatılmış, Basri
dc.contributor.authorTaşdemir, Aslı
dc.contributor.authorYılmaz, Hatice Çağlar
dc.date.accessioned2024-08-04T19:53:08Z
dc.date.available2024-08-04T19:53:08Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Nuclear factor E2-related factor-2 (Nrf2) regulates many cytoprotective antioxidants, and detoxifying enzymes, has been a hopeful approach for chemoprevention of cancer. We researched the chemopreventive impact of watercress on the DMBA- induced oxidative damage in the rat liver via the Nrf2/ARE signalling pathway in the present study. Material and Method: Female Wistar albino rats have categorized into three groups. The control was the first group, rats in the second and third groups were administered 7,12-dimethylbenz[a]anthracene (DMBA) (20 mg/kg b.w., i.p.) and rats in the third group were given daily doses of watercress (250 mg/kg b.w. Nasturtium officinale R.Br. for 4 weeks by oral gavage). Antioxidant and phase II detoxification enzyme activities, Nrf2 transcription factor level in liver, and serum ALT were determined. Also, histopathological analysis of the liver was performed. Results: We observed that watercress induces DNA-binding of Nrf2. It was related to increased enzyme activities of phase II detoxifying and the antioxidant. Our results also demonstrated that watercress ameliorated liver injury. Conclusion: Our data ensured considerable evidence that the dietary watercress ameliorates DMBA induced liver toxicity via regulating the activation of the Nrf2/ARE pathway which increases the expression of cytoprotective enzymes.en_US
dc.identifier.doi10.32322/jhsm.946969
dc.identifier.endpage942en_US
dc.identifier.issn2636-8579
dc.identifier.issue6en_US
dc.identifier.startpage936en_US
dc.identifier.trdizinid1155066en_US
dc.identifier.urihttps://doi.org/10.32322/jhsm.946969
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1155066
dc.identifier.urihttps://hdl.handle.net/11616/89486
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of health sciences and medicine (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the effect of watercress via nuclear factor- E2-related factor-2 pathway on 7,12-dimethylbenz[a] anthracene-induced oxidative damage in rat liveren_US
dc.typeArticleen_US

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