Effects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Study

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dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidbıçakcıoğlu, murat/ABB-5579-2020
dc.authorwosidIsik, Burak/A-6657-2018
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.contributor.authorSayan, H.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorBicakcioglu, M.
dc.contributor.authorToprak, H. I.
dc.contributor.authorIsik, B.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Donors are volunteers without any health problems. Therefore, the anesthetic management of donor safety is an important issue. Our aim in this study was to compare thoracic epidural anesthesia and general anesthesia effects on liver blood flow by means of liver function tests and indocyanine green and compared with living-donor liver transplantation. Methods. Subjects were divided into 2 equal groups: the control group (group I) and the epidural block group (group II, closed envelope method). In group II patients, the epidural catheter was inserted at the T6-8 level. In all patients, anesthesia was standardized with the use of lidocaine, fentanyl, and thiopental. Indocyanine green clearance test values before general anesthesia (T0), after induction of general anesthesia (T1), after transection (T2), and at postoperative 24 and 72 hours were recorded. Simultaneously, hemoglobin, hematocrit, platelet count, prothrombin time (PT), international normalized ratio (INR), total bilirubin, direct bilirubin, albumin, aspartate transaminase, and alanine transaminase values were analyzed. Results. Plasma disappearance rate (PDR) and retention at 15 minutes (R15) of indocyanine green were not statistically significant difference between groups (P > .05). Intragroup comparison of PDR and R15 values at times T1, T2, T3, and T4 showed that the values at T0 were statistically significant (P < .05). PT and INR values were significantly different for all times within each group (P < .05). It was concluded that the use of thoracic epidural anesthesia has no effect on global liver function and liver-related liability tests in patients undergoing elective liver donor surgery.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.033
dc.identifier.endpage1465en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093743en_US
dc.identifier.scopus2-s2.0-84931315869en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1462en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.033
dc.identifier.urihttps://hdl.handle.net/11616/96827
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800055en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneral-Anesthesiaen_US
dc.subjectHemodynamicsen_US
dc.titleEffects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Studyen_US
dc.typeArticleen_US

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