Expression of sirtuin 2 and 7 in placenta accreta spectrum

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dc.authoridFindik, Fatih Mehmet/0000-0001-9142-6127
dc.authorwosidFindik, Fatih Mehmet/HPF-1190-2023
dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorGurbuz, Sevim
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorDerin, Dilek Cam
dc.contributor.authorFindik, Fatih Mehmet
dc.date.accessioned2024-08-04T20:54:37Z
dc.date.available2024-08-04T20:54:37Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.METHODS: A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.RESULTS: It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).CONCLUSION: Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [220S416]; Inonu University Scientific Research Projects Unit [TYL-2021-2348]en_US
dc.description.sponsorshipConflicts of interest:the authors declare there is no conflicts of interest. Funding:Thisstudywas supported by grants from the Scientific and Technological Research Council of Turkey (grant number: 220S416) and Inonu University Scientific Research Projects Unit (grant number: TYL-2021-2348) .en_US
dc.identifier.doi10.1590/1806-9282.20230360
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue8en_US
dc.identifier.pmid37585995en_US
dc.identifier.scopus2-s2.0-85168251589en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20230360
dc.identifier.urihttps://hdl.handle.net/11616/101520
dc.identifier.volume69en_US
dc.identifier.wosWOS:001051569300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpithelial-mesenchymal transitionen_US
dc.subjectPlacenta accretaen_US
dc.subjectPlacenta previaen_US
dc.subjectSirtuin 2en_US
dc.subjectSirtuinsen_US
dc.titleExpression of sirtuin 2 and 7 in placenta accreta spectrumen_US
dc.typeArticleen_US

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