The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authorwosidköleli, ışıl/ABI-7318-2020
dc.authorwosidYILMAZ, Ercan/AAA-1818-2021
dc.authorwosidtemelli, Oztun/ABE-6986-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorGurocak, Simay
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorKoleli, Isil
dc.contributor.authorFaydali, Simge
dc.contributor.authorTemelli, Oztun
dc.contributor.authorYar, Tuba
dc.date.accessioned2024-08-04T20:45:54Z
dc.date.available2024-08-04T20:45:54Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DES). Material/Methods: The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. Results: Seventy-nine patients included 39 patients (49.4%) with stage II endometrial cancer, 25 patients (31.6%) with histologic grade 3 tumors, and 47 patients (59.5%) with endometrial cancer showing lymphovascular space invasion (LVSI). There were 45 patients (57.0%) who received external pelvic radiotherapy with an average dose of 46.0 Gy (range, 11.2-50.4 Gy), and 34 patients (43.0%) received vaginal brachytherapy (VBT) with an average dose of 21.5 Gy (range, 10-36 Gy). Multivariate analysis showed that tumor stage (HR, 4.066; 95% CI, 1.227-13.467; p=0.022) and histologic grade (HR, 16.652; 95% CI, 4.430-62.589; p<0.001) were independent predictors for OS. Increased serum CA-125 levels (HR, 1.136; 95% CI, 0.995-1.653; p=0.047) and histologic grade (HR, 3.236; 95% CI, 1.107-15.156; p=0.015) were independent predictors for DES. Adjuvant radiotherapy was not found to be significantly associated with improved OS (HR, 1.259; 95% CI, 0.518-3.058; p=0.612) or DES (HR, 1.056; 95% CI, 0.994-1.123; p=0.078). Conclusions: This retrospective study showed that in high-grade early-stage endometrial cancer treated with postoperative adjuvant radiotherapy, independent predictors for OS were tumor stage and grade. Adjuvant radiotherapy was not associated with improved OS or DES.en_US
dc.identifier.doi10.12659/MSM.913740
dc.identifier.endpage2818en_US
dc.identifier.issn1643-3750
dc.identifier.pmid30992424en_US
dc.identifier.scopus2-s2.0-85064970850en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2811en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.913740
dc.identifier.urihttps://hdl.handle.net/11616/98772
dc.identifier.volume25en_US
dc.identifier.wosWOS:000465299200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrial Neoplasmsen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleThe Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Studyen_US
dc.typeArticleen_US

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