Association between pan-immune inflammatory value and ulcerative colitis

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dc.contributor.authorYildirim, Aslihan Mete
dc.contributor.authorYildirim, Oguzhan
dc.date.accessioned2024-08-04T20:55:08Z
dc.date.available2024-08-04T20:55:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Ulcerative colitis is a chronic idiopathic disease that causes inflammation of the colon and rectum, progressing with relapses and remissions. Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are newly developed biomarkers. There are many studies in the literature showing the relationship between SII and PIV with malignancies and inflammatory diseases. In this study we aimed to determine the relationship between SII and PIV with the activity of ulcerative colitis. Materials and methods: 146 Ulcerative colitis patients were retrospectively investigated by the time of diagnosis based on clinical, endoscopic and histolopathological findings. Patients and healthy individuals SII and PIV levels were calculated and compared with each other; and Mayo, DUBLIN, UCIES endoscopic subscores of patients were also obtained. Roc curve analysis were used to determine the cut-off value for PIV. Results: SII (468.6 +/- 203.5 vs. 823.1 +/- 555.1; p < .001), PIV (288.2 +/- 159.9 vs. 912.2 +/- 924.1; p < .001), were statistically different between groups. PIV (OR: 1.157; (1.041-1.432), p = .036), was also observed to be the independent predictor of ulcerative colitis. The best cut off value of PIV in the prediction of ulcerative colitis was >= 506 with 89.6% sensitivity and 63.7% specificity (AUC = 0.812; 95% CI 0.763-0.854, p < .001). Conclusion: Based on the results of our study, we found that SII and PIV levels were significantly increased in ulcerative colitis patients at the time of diagnosis and were associated with disease severity in the endoscopic scores RACHMILEWITZ, UCEIS and DUBLIN scores, but not for MES score.en_US
dc.identifier.doi10.1080/03007995.2024.2316860
dc.identifier.endpage603en_US
dc.identifier.issn0300-7995
dc.identifier.issn1473-4877
dc.identifier.issue4en_US
dc.identifier.pmid38343292en_US
dc.identifier.scopus2-s2.0-85186581606en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage599en_US
dc.identifier.urihttps://doi.org/10.1080/03007995.2024.2316860
dc.identifier.urihttps://hdl.handle.net/11616/101858
dc.identifier.volume40en_US
dc.identifier.wosWOS:001176585400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCurrent Medical Research and Opinionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPan-immune inflammatory valueen_US
dc.subjectulcerative colitisen_US
dc.subjectsystemic inflammatory indexen_US
dc.titleAssociation between pan-immune inflammatory value and ulcerative colitisen_US
dc.typeArticleen_US

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