Occupational prolonged organic solvent exposure in shoemakers: brain MR spectroscopy findings

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dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridALTINOK, M. Tayfun/0000-0002-8779-9382
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authorwosidSaraç, Kaya/ABI-1091-2020
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidALTINOK, M. Tayfun/AAS-7079-2021
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.authorwosidPala, Nezih/ABA-1918-2021
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.contributor.authorAlkan, A
dc.contributor.authorKutlu, R
dc.contributor.authorHallac, T
dc.contributor.authorSigirci, A
dc.contributor.authorEmul, M
dc.contributor.authorPala, N
dc.contributor.authorAltinok, T
dc.date.accessioned2024-08-04T20:15:01Z
dc.date.available2024-08-04T20:15:01Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOur purpose was to investigate, by magnetic resonance (MR) spectroscopy, the metabolite changes in the brains of subjects in the shoemaking industry who had been chronically exposed to organic solvents. A total of 49 male subjects and 30 age-matched healthy volunteers underwent detailed neurological and psychiatric examinations. All subjects had long-echo [repetition time (TR) 2000 ms, echo time (TE) 136 ms] single-voxel MR spectroscopy. Voxels (15 x 15 x 15 mm(3)) were placed in the parietal white matter, thalamus, and basal ganglia. N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from thalamus, basal ganglia, and parietal white matter. Cho/Cr ratios in thalamus. basal ganglia, and parietal white matter were found to be significantly increased compared to controls. There was a positive correlation between basal ganglia Cho/Cr ratio and duration of exposure (r = 0.63). MR spectroscopy should be performed to reveal metabolite changes and determine the degree of brain involvement in solvent-related industry workers. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.mri.2004.01.070
dc.identifier.endpage713en_US
dc.identifier.issn0730-725X
dc.identifier.issue5en_US
dc.identifier.pmid15172065en_US
dc.identifier.scopus2-s2.0-2542495911en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1016/j.mri.2004.01.070
dc.identifier.urihttps://hdl.handle.net/11616/94103
dc.identifier.volume22en_US
dc.identifier.wosWOS:000221688400014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofMagnetic Resonance Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoccupational exposureen_US
dc.subjectsolventsen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.titleOccupational prolonged organic solvent exposure in shoemakers: brain MR spectroscopy findingsen_US
dc.typeArticleen_US

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