The protective effect of nebivolol on ischemia/reperfusion injury in rabbit spinal cord

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dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.contributor.authorIlhan, A
dc.contributor.authorYilmaz, HR
dc.contributor.authorArmutcu, F
dc.contributor.authorGurel, A
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:39Z
dc.date.available2024-08-04T20:13:39Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to investigate whether nebivolol has protective effects against neuronal damage induced by spinal cord ischemia/reperfusion (I/R). Twenty-one rabbits were divided into three groups: group I (control, no I/R), group II (only I/R) and group III (I/R+nebivolol). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Seventy-two hours postoperatively, the motor function of the lower limbs was evaluated in each animal. The animals were sacrificed at 72 h, and histopathological and biochemical analyses were carried out in the lumbar spinal cords. The motor deficit scores in nebivolol group were different from I/R group at 72 h (3.25 0.70 vs. 1.75 +/- 1.28, p=0.01). I/R produced a significant increase in the superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) and myeloperoxidase (MPO) activities in spinal cord tissue when compared with control group. Nebivolol treatment prevented the increase of all those enzymes activities produced by I/R. A significant decrease in spinal cord glutathione peroxidase (GSH-Px) level was seen in I/R group and nebivolol treatment prevented the decrement in the spinal cord tissue GSH-Px contents. On the other hand, I/R produced a significant increase in the spinal cord tissue malondialdehyde (MDA) and nitric oxide (NO) contents, this was prevented by nebivolol treatment. In conclusion, this study demonstrates a considerable neuroprotective effect of nebivolol on neurological, biochemical and histopathological status during periods of spinal cord I/R in rabbits. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2004.06.023
dc.identifier.endpage1160en_US
dc.identifier.issn0278-5846
dc.identifier.issue7en_US
dc.identifier.pmid15610928en_US
dc.identifier.scopus2-s2.0-10944229849en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1153en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2004.06.023
dc.identifier.urihttps://hdl.handle.net/11616/93767
dc.identifier.volume28en_US
dc.identifier.wosWOS:000225602200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia/reperfusion injuryen_US
dc.subjectnebivololen_US
dc.subjectoxidative damageen_US
dc.subjectspinal corden_US
dc.titleThe protective effect of nebivolol on ischemia/reperfusion injury in rabbit spinal corden_US
dc.typeReview Articleen_US

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