Clinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery: A Prospective Randomized Clinical Trial

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dc.authoridKarakaplan, Mustafa/0000-0001-9035-0319
dc.authoridErsoy, Yuksel/0000-0002-8035-4532
dc.authorwosidKarakaplan, Mustafa/IXN-3318-2023
dc.authorwosidElmali, Nurzat/A-1017-2014
dc.authorwosidSarikaya, Baran/AAA-8515-2021
dc.authorwosidErsoy, Yuksel/S-7503-2016
dc.contributor.authorGormeli, Gokay
dc.contributor.authorKarakaplan, Mustafa
dc.contributor.authorGormeli, Cemile Ayse
dc.contributor.authorSarikaya, Baran
dc.contributor.authorElmali, Nurzat
dc.contributor.authorErsoy, Yuksel
dc.date.accessioned2024-08-04T20:40:23Z
dc.date.available2024-08-04T20:40:23Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Osteochondral ankle injuries commonly affect the dome of the talus, and these injuries are a common cause of athletic disability. Various treatment options are available for these injuries including intra-articular hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. The purpose of this study was to compare the effects of HA and PRP as adjunct therapies after arthroscopic microfracture in osteochondral lesions (OCLs) of the talus. Methods: In this prospective, randomized blinded study, 40 patients with talar OCLs in their ankle joints were treated with arthroscopic debridement and a microfracture technique. Thirteen randomly selected patients received PRP, 14 patients received HA, and the remaining 13 patients received saline as a control group. The participants were assessed using the American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog pain scale (VAS) scores after a 15.3-month (range, 11-25 months) follow-up. Results: Postoperatively, all the groups exhibited significantly increased AOFAS scores and decreased VAS scores compared with their preoperative results (P < .005). The AOFAS scores were significantly increased in the PRP group versus the HA and control groups (P < .005), although the increased AOFAS scores in the HA group versus the control group were also significant (P < .005). Similar to the AOFAS scores, the decrease in the VAS scores was significantly lower in the PRP group versus the HA and control groups (P < .005). In addition, the HA group had significantly lower VAS scores than the control group (P < .005). Conclusion: Both PRP and HA injections improved the clinical outcomes of patients who underwent operation for talar OCLs in the midterm period and can be used as adjunct therapies for these patients. Because a single dose of PRP provided better results, we recommend PRP as the primary adjunct treatment option in the talar OCL postoperative period. Level of Evidence: Level I, prospective randomized study.en_US
dc.identifier.doi10.1177/1071100715578435
dc.identifier.endpage900en_US
dc.identifier.issn1071-1007
dc.identifier.issn1944-7876
dc.identifier.issue8en_US
dc.identifier.pmid25825393en_US
dc.identifier.scopus2-s2.0-84938563388en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage891en_US
dc.identifier.urihttps://doi.org/10.1177/1071100715578435
dc.identifier.urihttps://hdl.handle.net/11616/96887
dc.identifier.volume36en_US
dc.identifier.wosWOS:000359152600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofFoot & Ankle Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectosteochondral lesionsen_US
dc.subjecttalusen_US
dc.subjectplatelet-rich plasmaen_US
dc.subjecthyaluronic aciden_US
dc.subjectmicrofractureen_US
dc.titleClinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery: A Prospective Randomized Clinical Trialen_US
dc.typeArticleen_US

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