Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

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dc.authoridYenilmez, Engin/0000-0002-0755-4394
dc.authoridSENER, SILA OZLEM/0000-0001-7679-7165
dc.authorwosidSENER, Sila Ozlem/AAT-5338-2020
dc.contributor.authorSener, Sila Ozlem
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorKanbolat, Seyda
dc.contributor.authorKorkmaz, Nuriye
dc.contributor.authorBadem, Merve
dc.contributor.authorHanci, Hatice
dc.contributor.authorDirmenci, Tuncay
dc.date.accessioned2024-08-04T20:50:16Z
dc.date.available2024-08-04T20:50:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObesity is a risk factor for metabolic disorders causes serious health problems and economic costs globally. Some Cirsium genus has been reported to possess anti-obesity effect and traditional uses for vascular diseases, anti-inflammatory and diuretic effects. This study aims to investigate the therapeutic value of endemic Cirsium species for obesity treatment. C. balikesirense Yildiz, Arabaci & Dirmenci (CB), C. nerimaniae Yildiz, Dirmenci & Arabaci (CN) and C. sommieri Petr. (CS) were selected for the study. High-fat diet (HFD) induced obese Sprague Dawley rats were employed for in vivo studies. The extract obtained aerial parts of Cirsium species were applied to rats orally for 8 weeks. To interpret the antiobesity activity, body weight of the rats were measured. Also, biochemical, histopathological and quantitative real-time PCR (RT-PCR) analysis were performed on rats. Bioactivity-guided fractionation studies were carried out guidance with in vitro lipase enzyme inhibition. The structures of the pure compounds purified using various chromatographic techniques were determined by spectroscopic methods. Oral administration of the extracts and orlistat decreased in body weights, adipocytes size, levels of serum low-density lipoprotein (LDL), triglyceride (TG), leptin levels, lipase, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and increased levels of serum high-density lipoprotein (HDL), adiponectin. According to RT-PCR analysis, the extracts reduced the levels of key transcription factors in adipogenesis and fatty acid synthase (FAS). Bioactivity-guided fractionation studies led to isolation of active compounds as syringin, cimidahurinin, astragalin, afzelin, lupeol, and psi-taraxasterol. In conclusion, CB, CN, CS and their isolated compounds were uncovered to be hopeful as a candidate for antiobesity therapeutics. (C) 2021 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Council [116Z475]; Ankara University Scientific Research Projects Unit [18H0237004]; Karadeniz Technical University Scientific Research Projects Unit [TSA-2017-6866]en_US
dc.description.sponsorshipWe would like to acknowledge the Turkish Scientific and Technical Research Council (Project no: 116Z475) , Ankara University Scientific Research Projects Unit (Project no: 18H0237004) , and Karadeniz Technical University Scientific Research Projects Unit (Project no: TSA-2017-6866) for funding of the study.en_US
dc.identifier.doi10.1016/j.sajb.2021.05.004
dc.identifier.endpage254en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85107113212en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2021.05.004
dc.identifier.urihttps://hdl.handle.net/11616/99963
dc.identifier.volume141en_US
dc.identifier.wosWOS:000707396300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipogenesisen_US
dc.subjectAntiobesity effecten_US
dc.subjectBioactivity guided fractionationen_US
dc.subjectCirsiumen_US
dc.subjectLipaseen_US
dc.titleInvestigation of therapeutic potential of three endemic Cirsium species for global health problem obesityen_US
dc.typeArticleen_US

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