Effect of resveratrol on tubular damage and interstitial fibrosis in kidneys of rats exposed to cigarette smoke

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorKurus, Meltem
dc.contributor.authorUgras, Murat
dc.contributor.authorEsrefoglu, Mukaddes
dc.date.accessioned2024-08-04T20:31:21Z
dc.date.available2024-08-04T20:31:21Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of resveratrol on kidney tissue of rats exposed to cigarette smoke. Forty adult male Wistar Albino rats were divided into four groups. Animals in group 1 was the control group. For 6 weeks, group 2 was exposed to cigarette smoke; group 3 received daily intraperitoneal injections of resveratrol (10 mg/kg/d); and group 4 was exposed to both cigarette smoke and intraperitoneal resveratrol. All rats were sacrificed with cervical dislocation. The kidney tissues were obtained, fixed in Bouin's fixative and embeded in paraffin blocks. Samples were sectioned to 4-5 microns thickness, stained with hematoxylin/eosin (H/E), Masson's trichromic, periodic acid-schiff (PAS) and were examined by light microscopy for tubular injury and interstitial fibrosis. Results were compared by non-parametric tests. Hydropic degeneration, tubular atrophy, tubulo-interstitial fibrosis, interstitial cell infiltration, vacuolar degeneration and desquamation were prominent in group 2. In group 4, hydropic degeneration, epithelial cell vacuolization and desquamation was not observed, but occasional tubular atrophy and dilation were observed. Our study suggests that, some morphological alterations in the rat kidney, due to cigarette smoke may be prevented by resveratrol.en_US
dc.identifier.doi10.1177/0748233709346755
dc.identifier.endpage544en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue8en_US
dc.identifier.pmid19825860en_US
dc.identifier.scopus2-s2.0-70350012315en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.1177/0748233709346755
dc.identifier.urihttps://hdl.handle.net/11616/94891
dc.identifier.volume25en_US
dc.identifier.wosWOS:000270763300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCigarette smokeen_US
dc.subjectresveratrolen_US
dc.subjectkidneyen_US
dc.subjecthistopathologyen_US
dc.titleEffect of resveratrol on tubular damage and interstitial fibrosis in kidneys of rats exposed to cigarette smokeen_US
dc.typeArticleen_US

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