Clinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia)

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dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridcelik, osman/0000-0003-2131-2866
dc.authorwosidCaglayan, Murat/AGY-9057-2022
dc.authorwosidSonmez, Alper/H-8588-2019
dc.authorwosidsahin, mustafa/AAH-3394-2019
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.contributor.authorHaymana, Cem
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorTasci, Ilker
dc.contributor.authorCakal, Erman
dc.contributor.authorSalman, Serpil
dc.contributor.authorErtugrul, Derun
dc.contributor.authorAta, Naim
dc.date.accessioned2024-08-04T20:50:23Z
dc.date.available2024-08-04T20:50:23Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and prognosis of COVID-19 disease in non-diabetic patients. Methods A nationwide retrospective cohort of non-diabetic patients with confirmed COVID-19 infection from 11 March to 30 May 2020 in the Turkish Ministry of Health database was investigated. The patients were stratified into three groups according to blood glucose levels which were <100 mg/dL in group-1, in the range of 100-139 mg/dl in group-2, and the range of 140-199 mg/dl in group-3. Clinical characteristics and outcomes were compared among the groups. The primary outcome was mortality. Results A total of 12,817 non-diabetic patients (median age [IQR]: 44 [25] years, females: 50.9%) were included. Patients in group-2 (5%) and group-3 (14%) had higher mortality rates than patients in group-1 (2.1%). The rates of hospitalization, hospital stays longer than 8 days, intensive care unit (ICU) admission, ICU stay more than 6 days, and mechanical ventilation were also significantly higher in group-3 patients. Likewise, glucose levels in the range of 140-199 mg/dL were an independent associate of mortality and composite of ICU admission and/or mechanical ventilation. Conclusion Hyperglycemia at the time of COVID-19 diagnosis is associated with poor prognosis in non-diabetic patients. Clinicians should be more careful in the treatment of non-diabetic COVID-19 patients with hyperglycemia.en_US
dc.identifier.doi10.1007/s12020-021-02789-9
dc.identifier.endpage269en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue2en_US
dc.identifier.pmid34156609en_US
dc.identifier.scopus2-s2.0-85108585656en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-021-02789-9
dc.identifier.urihttps://hdl.handle.net/11616/100001
dc.identifier.volume73en_US
dc.identifier.wosWOS:000664391800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectHyperglycemiaen_US
dc.subjectHospitalizationen_US
dc.subjectICU admissionen_US
dc.subjectMechanical ventilationen_US
dc.subjectMortalityen_US
dc.titleClinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia)en_US
dc.typeArticleen_US

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