Plausible PEPPSI catalysts for direct C-H functionalization of furans and pyrroles

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dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorMunir, Naima
dc.contributor.authorGurbuz, Navin
dc.contributor.authorZafar, M. Naveed
dc.contributor.authorEvren, Enes
dc.contributor.authorSen, Betul
dc.contributor.authorAygun, Muhittin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:54:41Z
dc.date.available2024-08-04T20:54:41Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe worth of bi(hetero)arenes in ongoing medicinal and industrial research fields promotes their efficient synthesis by Pd-PEPPSI-bearing NHC spectator ligands encapsulated as site-selective direct C-H functionalization agents. Eight new asymmetric N-heterocyclic carbenes ligands and their plausible pyridine-assisted Pd (II) complexes are reported in this work. The synthesized compounds were thoroughly characterized by respective spectroscopic techniques, such as 1H, 13C, FTIR and elemental analysis. The structures of synthesized pro-ligand salts and complexes were determined by Single Crystal XRD. The on/off mechanism of pyridine assisted Pd-NHC complexes made them the best C-H functionalized catalysts for regioselective C5 arylated products. Five membered heterocyclic compounds such as 2-acetyl furan, furfuryl acetate and 1-methyl-2-pyrrole-carboxylaldehyde were treated with numerous aryl bromides under optimal catalytic reaction conditions. Furfuryl acetate was used for the first time as a substrate in the present research work. Interestingly, all the prepared catalysts possessed essential structural features that facilitated the formation of desired coupled products in quantitative yield with excellent selectivity.en_US
dc.description.sponsorshipTurkiye Burslari Research Scholarship [21PK070710]; Inonue University Research and Catalysis Centre in Ismail Ozdemir research laboratory [2010.KB.FEN.13]; Eyluel University [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe author gratefully acknowledged her deep appreciation to the Turkiye Burslari Research Scholarship for her Ph.D. research funding (Application # 21PK070710). This study was supported by Inonue University Research and Catalysis Centre in Ismail Ozdemir research laboratory. Dokuz Eyluel University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13) is also greatly acknowledged.en_US
dc.identifier.doi10.1016/j.molstruc.2023.136679
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85171795735en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.136679
dc.identifier.urihttps://hdl.handle.net/11616/101582
dc.identifier.volume1295en_US
dc.identifier.wosWOS:001083583000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectPd-PEPPSI complexesen_US
dc.subjectC-H bond arylationen_US
dc.subjectDirect arylation reactionsen_US
dc.titlePlausible PEPPSI catalysts for direct C-H functionalization of furans and pyrrolesen_US
dc.typeArticleen_US

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