Increased membrane turnover in the brain in cutaneous anthrax without central nervous system disorder: A magnetic resonance spectroscopy study

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dc.authoridKayabas, Uner/0000-0002-5323-0796
dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidKayabas, Uner/JRX-1616-2023
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorBayindir, Yasar
dc.contributor.authorFirat, Ahmet K.
dc.contributor.authorKayabas, Uner
dc.contributor.authorAlkan, Alpay
dc.contributor.authorYetkin, Funda
dc.contributor.authorKarakas, Hakki M.
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:35:54Z
dc.date.available2024-08-04T20:35:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCutaneous anthrax, caused by Bacillus anthracis contacting the skin, is the most common form of human anthrax. Recent studies implicate the presence of additional, possibly toxin-related subtle changes, even in patients without neurological or radiological findings. In this study, the presence of subtle changes in cutaneous anthrax was investigated at the metabolite level using magnetic resonance spectroscopy. Study subjects were consisted of 10 patients with cutaneous anthrax without co-morbid disease and/or neurological findings, and 13 healthy controls. There were no statistical differences in age and gender between two groups. The diagnosis of cutaneous anthrax was based on medical history, presence of a typical cutaneous lesion, large gram positive bacilli on gram staining and/or positive culture for B. anthracis from cutaneous samples. Brain magnetic resonance imaging examination consisted of conventional imaging and single-voxel magnetic resonance spectroscopy. Magnetic resonance spectroscopy was performed by using point-resolved spectroscopy sequence (TR: 2000 ms, TE: 136 ms, 128 averages). Voxels of 20 mm x 20 mm x 20 mm were placed in normal-appearing parietal white matter to detect metabolite levels. Cerebral metabolite peaks were measured in normal appearing parietal white matter. N-acetyl aspartate/creatine and choline/creatine ratios were calculated using standard analytical procedures. Patients and controls were not statistically different regarding parietal white matter N-acetyl aspartate/creatine ratios (p = 0.902), a finding that implicates the conservation of neuronal and axonal integrity and neuronal functions. However, choline/creatine ratios were significantly higher in patient groups (p = 0.001), a finding implicating an increased membrane turnover. In conclusion, these two findings point to a possibly anthrax toxins-related subtle inflammatory reaction of the central nervous system at the cellular level. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2012.03.027
dc.identifier.endpage46en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.issue1en_US
dc.identifier.pmid22543072en_US
dc.identifier.scopus2-s2.0-84861462020en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2012.03.027
dc.identifier.urihttps://hdl.handle.net/11616/95668
dc.identifier.volume79en_US
dc.identifier.wosWOS:000305375600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProton Mr Spectroscopyen_US
dc.subjectAppearing White-Matteren_US
dc.subjectDiffusion-Weighted Mren_US
dc.subjectToxinen_US
dc.subjectMeningoencephalitisen_US
dc.subjectFeaturesen_US
dc.subjectCholineen_US
dc.subjectLesionsen_US
dc.titleIncreased membrane turnover in the brain in cutaneous anthrax without central nervous system disorder: A magnetic resonance spectroscopy studyen_US
dc.typeArticleen_US

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