The effect of lycopene on the ototoxicity induced by cisplatin

Basit Öğe Kaydı
dc.contributor.authorÇiçek, Mehmet Turan
dc.contributor.authorKalcıoğlu, Mahmut Tayyar
dc.contributor.authorBayındır, Tuba
dc.contributor.authorToplu, Yüksel
dc.contributor.authorIraz, Mustafa
dc.date.accessioned2020-06-28T08:56:18Z
dc.date.available2020-06-28T08:56:18Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractÖz: Başlık (İngilizce): Öz (İngilizce): Background/aim: To determine the efficacy of lycopene, which is considered an antioxidant agent, in decreasing the cochlear damage induced by cisplatin. Materials and methods: A total of 38 rats were randomized into 4 groups: control, cisplatin, cisplatin + lycopene, and lycopene-treated groups. In all groups, the distortion-product otoacoustic emission measurements were performed on days 0, 1, 2, and 5. Results: There were no significant differences between the control and lycopene groups at any frequencies. In the cisplatin group, the statistically significant differences were found in the measurements taken between day 0 and day 5 at all frequencies and between days 1 and 5 and days 2 and 5 at some frequencies (P < 0.05). In the cisplatin + lycopene group, a statistically significant difference was found at some frequencies between the measurements taken on days 0 and 5, days 1 and 5, and days 2 and 5 (P < 0.05). Contrary to the results found in the cisplatin group, hearing ability in the lycopene-treated group was observed as being preserved at low frequencies in the measurements taken on days 0 and 5 and days 2 and 5. Conclusion: The data of this study suggest that lycopene can prevent the development of ototoxicity induced by cisplatin, especially at low frequencies. Studies on this issue with longer durations and different dose ranges may contribute to the identification of potentially prophylactic effects of lycopene against cisplatin ototoxicity at higher frequencies, as well.en_US
dc.identifier.citationMehmet Turan Ç., MAHMUT TAYYAR K., TUBA B., Yüksel T., Mustafa I. (2014). The effect of lycopene on the ototoxicity induced by cisplatin, Turkish Journal of Medical Sciences, İnönü Üniversitesi, Malatya.en_US
dc.identifier.endpage585en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid25551925en_US
dc.identifier.startpage582en_US
dc.identifier.trdizinid213122en_US
dc.identifier.urihttps://hdl.handle.net/11616/16129
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/213122
dc.identifier.volume44en_US
dc.identifier.wosWOS:000336959100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Journal of Medical Sciencesen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleThe effect of lycopene on the ototoxicity induced by cisplatinen_US
dc.typeArticleen_US

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