Neostigmin ile barsak peristaltizminin uyarılmasının peritoneal adezyon oluşumu üzerine etkisi
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Dosyalar
Tarih
1995
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Her iki cinsten 20 Wistar rat'a ketamin hidroklorür anestezisi altında 3 cm'lik median kesi ile laparatomi yapıldı. Omentum bir yerinden ipek ile bağlandı. Orta hattın 3 cm sağında 4 x 1 cm'lik periton ve adele defekti oluşturuldu. Bu defekt 5 adet 3-0 ipek sütürle tek tek kapatıldı. Çekum ön yüzüne fırça ile 1 cm2'lik erozyon oluşturuldu. Denekler iki gruba ayrıldı. 10 tanesine 7 gün süre ile 25 gr/kg/gün intramusküler neostigmin uygulandı. Tüm denekler postoperatif 10. gün sakrifiye edildi ve adezyonlar değerlendirildi. Kontrol grubu ile neostigmin verilen grup arasında istatistiksel olarak anlamlı fark bulundu (p < 0.05). Postoperatif adezyonların önlenmesinde barsak peristaltizmi uyarılmasının katkısı olabileceği sonucuna varıldı.
Twenty Wistar rats were anaesthetised with ketamine chloride and the abdomen was opened through a midline incision 3 cm long. Omentum was tied with silk suture in one part. At 3 cm right of the midline, 4x1 cm of defect including muscle and underlying peritoneum was performed. This defect was sutured by 3-0 silk from 5 sides. One cm2 erosion was formed on anterior surface of the caecum by brushing. Then, rats were separated into two groups.25 µgr/kg/im/day neostigmine was administered to study group for 7 days. All rats were sacrified and evaluated at the postoperative tenth day. There was significant difference between the control and neostigmine (p < 0.05). It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions.
Twenty Wistar rats were anaesthetised with ketamine chloride and the abdomen was opened through a midline incision 3 cm long. Omentum was tied with silk suture in one part. At 3 cm right of the midline, 4x1 cm of defect including muscle and underlying peritoneum was performed. This defect was sutured by 3-0 silk from 5 sides. One cm2 erosion was formed on anterior surface of the caecum by brushing. Then, rats were separated into two groups.25 µgr/kg/im/day neostigmine was administered to study group for 7 days. All rats were sacrified and evaluated at the postoperative tenth day. There was significant difference between the control and neostigmine (p < 0.05). It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions.
Açıklama
[Journal of Turgut Özal Medical Center 1(1):10-13,1994]
Anahtar Kelimeler
Neostigmin, Peritoneal adezyon, Neostigmine, Peritoneal adhesion
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
1
Künye
Erbilen, M.,Sönmez, A.Süha., Arab, A.,Şahin, M.,Ertaş, E.,Bülbüloğlu, E.,
(1994).Neostigmin ile barsak peristaltizminin uyarılmasının peritoneal adezyon oluşumu üzerine etkisi.Turgut Özal Tıp Merkezi Dergisi, 1 (1).10-13 ss.
