Vitreoscilla hemoglobin renders Enterobacter aerogenes highly susceptible to heavy metals

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridGeckil, Hikmet/0000-0003-0070-0691
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGeckil, Hikmet/F-7647-2012
dc.contributor.authorGeckil, H
dc.contributor.authorArman, A
dc.contributor.authorGencer, S
dc.contributor.authorAtes, B
dc.contributor.authorYilmaz, HR
dc.date.accessioned2024-08-04T20:14:43Z
dc.date.available2024-08-04T20:14:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWhen expressed in heterologous microorganisms Vitreoscilla hemoglobin (VHb) acts as oxygen storage and causes a higher oxygen uptake. In this study, the effect of this protein on growth, sensitivity and antioxidant properties of Enterobacter aerogenes exposed to metal stress was investigated. The strain expressing VHb was more sensitive to mercury and cadmium as the minimal inhibitory concentration (MIC) for these metals was up to 2-fold lower in this strain than the host and the recombinant strain carrying a comparable plasmid. At lower concentrations than MIC, the metals partially limited growth and caused an inhibition proportional to metal concentration applied. The growth pattern of VHb expressing strain was also distinctly different from other two non-hemoglobin strains. The hemoglobin containing strain showed substantially higher superoxide dismuates (SOD) activity than the non-hemoglobin strains, while catalase levels were similar in all strains. All strains exposed to copper, however, showed similar MIC values, growth patterns, and SOD and catalase levels.en_US
dc.identifier.doi10.1007/s10534-004-1216-x
dc.identifier.endpage723en_US
dc.identifier.issn0966-0844
dc.identifier.issn1572-8773
dc.identifier.issue6en_US
dc.identifier.pmid15689114en_US
dc.identifier.scopus2-s2.0-18444365608en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage715en_US
dc.identifier.urihttps://doi.org/10.1007/s10534-004-1216-x
dc.identifier.urihttps://hdl.handle.net/11616/93922
dc.identifier.volume17en_US
dc.identifier.wosWOS:000226552000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiometalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitreoscilla hemoglobinen_US
dc.subjectbacterial hemoglobinen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant systemsen_US
dc.subjectcatalaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleVitreoscilla hemoglobin renders Enterobacter aerogenes highly susceptible to heavy metalsen_US
dc.typeArticleen_US

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