The effect of topical parasympathomimetics on corneal epithelial healing in rabbits

Basit Öğe Kaydı
dc.contributor.authorEr, H
dc.date.accessioned2024-08-04T20:11:55Z
dc.date.available2024-08-04T20:11:55Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCorneal wound healing is an important process that involves interaction between the different corneal cell layers, growth factors, and environmental conditions. More powerful therapies for the treatment of delayed epithelial wound healing are still being proposed. The objective of this study is to investigate the effects of the direct-acting parasympathomimetic agents on the healing process of corneal epithelium in rabbits. The corneal epithelial defects, 10 mm in diameter, were created in 32 eyes of 16 island rabbits by combination of chemical debridement using n-heptanol and mechanical scraping. Animals were randomly divided into four groups. Groups 1, 2 and 3 were treatment groups; each group consisted of four rabbits (8 eyes). The animals in these groups were treated with topical 1% acetylcholine (ACh), 2% pilocarpine, and 0.75% carbachol drops respectively. In group 4, four rabbits (8 eyes) were used as control group and left for spontaneous healing. The length acid area of the defect were measured at days 3,6,9,12,15,18 and 22 after wounding. Areas of the photographically documented fluorescein-stained defects were measured by planimetry. All eyes in the treatment groups reepithelialized completely. The duration for reepithelialization in Groups 1 and 2 was 12 days, and 18 days for Group 3. In the control group reepithelialization occurred within 22 days. The healing rates of corneal epithelium were statistically significantly faster in all treatment groups as compared with the control group at all times (p=0.0001 to 0.0.0279). Although the rates of wound healing varied, all of the parasympathomimetics used in the present study were found to facilitate wound healing. Our results indicate that direct-acting cholinergic agents, especially ACh and pilocarpine, may have an important therapeutic role in the treatment of severe corneal epithelial injury.en_US
dc.identifier.endpage335en_US
dc.identifier.issn0012-4486
dc.identifier.issue4en_US
dc.identifier.pmid9665290en_US
dc.identifier.scopus2-s2.0-0031399261en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://hdl.handle.net/11616/93091
dc.identifier.volume93en_US
dc.identifier.wosWOS:000074285900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publen_US
dc.relation.ispartofDocumenta Ophthalmologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorneaen_US
dc.subjectwound healingen_US
dc.subjectmuscarinic receptoren_US
dc.subjectparasympathomimeticsen_US
dc.titleThe effect of topical parasympathomimetics on corneal epithelial healing in rabbitsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu