Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine-based tripeptides

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dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridCAPAN, IRFAN/0000-0002-9555-1555
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authoridSEKERCI, Guldeniz/0000-0002-0811-4454
dc.authoridCaliskan, Eray/0000-0003-2399-4100
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidŞekerci, Güldeniz/IVH-2033-2023
dc.authorwosidCAPAN, IRFAN/AAE-4102-2022
dc.authorwosidCaliskan, Eray/W-6973-2018
dc.contributor.authorCaliskan, Eray
dc.contributor.authorKaplan, Alpaslan
dc.contributor.authorSekerci, Guldeniz
dc.contributor.authorCapan, Irfan
dc.contributor.authorTekin, Suat
dc.contributor.authorErkan, Sultan
dc.contributor.authorKoran, Kenan
dc.date.accessioned2024-08-04T20:53:45Z
dc.date.available2024-08-04T20:53:45Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPeptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxicity properties of all compounds against human cancer cell lines (MCF-7), ovarian (A2780), prostate (PC-3), and colon cancer cell lines (Caco-2) were determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay method, and % cell viability and logIC50 values of the compounds were calculated. Significant decreases in cell viability were observed in all cells (p < 0.05). The comet assay method was used to understand that the compounds that showed a significant decrease in cell viability had this effect through DNA damage. Most of the compounds exhibited cytotoxicity by DNA damage mechanism. Besides, their interactions between investigated molecule groups with PDB ID: 3VHE, 3C0R, 2ZCL, and 2HQ6 target proteins corresponding to cancer cell lines, respectively, were investigated by docking studies. Finally, molecules with high biological activity against biological receptors were determined by ADME analysis.en_US
dc.description.sponsorshipTUBITAK [118Z286]en_US
dc.description.sponsorshipACKNOWLEDGMENTS The authors are grateful to TUBITAK (Grant number 118Z286) for financial support for this project. Additionally, this work was produced from Alpaslan KAPLAN's PhD thesis.en_US
dc.identifier.doi10.1002/jbt.23388
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8en_US
dc.identifier.pmid37243846en_US
dc.identifier.scopus2-s2.0-85160815460en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23388
dc.identifier.urihttps://hdl.handle.net/11616/101382
dc.identifier.volume37en_US
dc.identifier.wosWOS:000994138400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADMEen_US
dc.subjectcytotoxicityen_US
dc.subjectDNA damageen_US
dc.subjectmolecular dockingen_US
dc.subjectpeptidesen_US
dc.titleSynthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine-based tripeptidesen_US
dc.typeArticleen_US

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