Damaging Effects of Total Parenteral Nutrition Formula on Vascular Endothelium

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dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridDemircan, Mehmet/0000-0002-4022-1276;
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorGurunluoglu, Kubulay
dc.contributor.authorKaraman, Abdurrahman
dc.contributor.authorMizrak, Bulent
dc.date.accessioned2024-08-04T20:41:13Z
dc.date.available2024-08-04T20:41:13Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Sepsis in one of the most serious complications that can occur during total parenteral nutrition (TPN) procedures. In this experimental study, we investigated the effects of TPN, with or without lipid emulsion, on vascular endothelial damage. Methods: In total, 50 rabbits were used, divided into 5 groups of 10 each. TPN with lipids (group 1), TPN without lipids (group 2), and 0.09% saline (group 3) were given for 10 days via a central venous catheter. Group 4 received no treatment other than placement of a central venous catheter for 10 days. Group 5 was a control group. At the end of day 10, rabbits were sacrificed and tissue samples of liver, kidney, and inferior vena cava were prepared and examined by immunohistochemical methods for vascular cellular adhesion molecule (VCAM)-1 expression. Results: In tissue sections of liver, kidney, and inferior vena cava, VCAM-1 activity was increased prominently in TPN with and without lipids compared with the control group. VCAM-1 activity in the TPN with lipids group was decreased versus the TPN without lipids group (P > 0.05). Conclusions: The TPN procedure results in vascular endothelial cell damage not only in the vein where the solution is introduced but also in other parts of the vascular system. Even if it is not statistically significant, lipids in the TPN formula may decrease this endothelial cell damage, as shown by immunohistochemistry.en_US
dc.description.sponsorshipTUBITAK (the Scientific and Technological Research Council of Turkey) [105S497, SBAG-HD-85]en_US
dc.description.sponsorshipThis study was supported by TUBITAK (the Scientific and Technological Research Council of Turkey; Project number: 105S497, SBAG-HD-85).en_US
dc.identifier.doi10.1097/MPG.0000000000000828
dc.identifier.endpage468en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue4en_US
dc.identifier.pmid25905544en_US
dc.identifier.scopus2-s2.0-84942509660en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage464en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000000828
dc.identifier.urihttps://hdl.handle.net/11616/96990
dc.identifier.volume61en_US
dc.identifier.wosWOS:000369587700023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlipid emulsionsen_US
dc.subjectsepsisen_US
dc.subjecttotal parenteral nutritionen_US
dc.subjectvascular endothelial damageen_US
dc.subjectvascular cellular adhesion molecule-1en_US
dc.titleDamaging Effects of Total Parenteral Nutrition Formula on Vascular Endotheliumen_US
dc.typeArticleen_US

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