Trends in Tumor Indices in Relation to Increased Hepatocellular Carcinoma Size: Evidence for Tumor Evolution as a Function of Growth

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridDonghia, Rossella/0000-0002-9140-673X
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorCarr, Brian I.
dc.contributor.authorGuerra, V.
dc.contributor.authorDonghia, R.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-04T20:48:57Z
dc.date.available2024-08-04T20:48:57Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground The prognosis of HCC depends in large measure on maximum tumor diameter (MTD). Aims To examine characteristics of tumor aggressiveness over an MTD range of< 2 to 8 cm. Methods A large HCC database was examined retrospectively for trends in serum alpha-fetoprotein (AFP), and percent of patients with macroscopic portal vein thrombosis (PVT) or tumor multifocality. Results There was a significant trend to increased serum AFP levels and percent of patients with PVT, for each,p < 0.001. Within those trends, there were clearly identifiable sub-trends for variations of AFP or percent PVT patients, associated with specific MTD ranges. Calculation of the fold increase for either AFP or percent PVT patients over distinct MTD ranges showed a greater increase of AFP or percent PVT patients compared with the related MTD increase. Interestingly, the increase in percent PVT was mainly independent of AFP. Conclusions Patterns of AFP and PVT increase can be discerned with increasing MTD, which are nonlinear. The greater fold increase in tumor aggressiveness factors compared with MTD suggests that HCCs may change with increasing size to a more aggressive phenotype. Baseline HCC biopsies might therefore be insufficient in future rational HCC management, and repeated liquid biopsies have potential in following HCC evolution and thus choices of therapies.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by the NIH grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1007/s12029-020-00530-9
dc.identifier.endpage1219en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid33006073en_US
dc.identifier.scopus2-s2.0-85091765427en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1215en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00530-9
dc.identifier.urihttps://hdl.handle.net/11616/99561
dc.identifier.volume51en_US
dc.identifier.wosWOS:000574370100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHCCen_US
dc.subjectMTDen_US
dc.subjectPVTen_US
dc.subjectEvolutionen_US
dc.titleTrends in Tumor Indices in Relation to Increased Hepatocellular Carcinoma Size: Evidence for Tumor Evolution as a Function of Growthen_US
dc.typeArticleen_US

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