Colchicine-Tolerant vs. Resistant Familial Mediterranean Fever: Comparative Analysis of Clinical, Psychosocial Characteristics and Quality of Life

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dc.contributor.authorKaya, Zeynep
dc.contributor.authorSag, Sinem
dc.contributor.authorKaya, Mehmet Nur
dc.contributor.authorZontul, Sezgin
dc.contributor.authorYolbas, Servet
dc.date.accessioned2026-04-04T13:31:02Z
dc.date.available2026-04-04T13:31:02Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/Objectives: Familial Mediterranean Fever (FMF) is a chronic autoinflammatory disease in which some patients develop resistance to colchicine, resulting in persistent attacks and increased disease burden. This study aimed to compare clinical characteristics, disease activity, psychological status, and quality of life between colchicine-tolerant and colchicine-resistant FMF patients, and to identify clinical factors independently associated with colchicine resistance. Methods: This exploratory cross-sectional observational study was conducted in 120 FMF patients followed at a tertiary rheumatology center. Patients were classified as colchicine-tolerant or colchicine-resistant. Disease activity and damage were assessed using the International Severity Scoring System for FMF (ISSF) and the Autoinflammatory Disease Damage Index (ADDI). Quality of life was evaluated using the FMF-Health-Related Quality of Life (FMF-HQL) and WHO Quality of Life-BREF (WHOQoL-BREF) questionnaires. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Results: Colchicine-resistant patients had significantly higher attack frequency and disease activity scores (p < 0.001). Quality of life was impaired, with higher FMF-HQL and lower WHOQoL-BREF scores across all domains (p < 0.001). Anxiety and depression scores were also higher. ISSF and Doctor Global Assessment (DGA) were independently associated with colchicine resistance. Conclusions: Colchicine resistance in FMF was associated with increased disease activity, impaired quality of life, and greater psychological burden.
dc.identifier.doi10.3390/jcm15051784
dc.identifier.issn2077-0383
dc.identifier.issue5
dc.identifier.pmid41827201
dc.identifier.scopus2-s2.0-105032781029
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm15051784
dc.identifier.urihttps://hdl.handle.net/11616/108538
dc.identifier.volume15
dc.identifier.wosWOS:001714426100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectfamilial mediterranean fever
dc.subjectcolchicine resistance
dc.subjectdisease activity
dc.subjectquality of life
dc.subjectpsychological burden
dc.titleColchicine-Tolerant vs. Resistant Familial Mediterranean Fever: Comparative Analysis of Clinical, Psychosocial Characteristics and Quality of Life
dc.typeArticle

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