Enantioseparation of Some New 1-(2-Naphthyl)-1-ethanol Ester Derivatives by HPLC on Chiralcel OD
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Heidelberg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The direct enantiomeric resolution of racemic 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters, 1-(naphthalene-2-yl)ethanol esters, and 1-(1-hydroxynaphthalene-2-yl)-2-(1H-imidazole-1-yl)ethanol on silica-based cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD) column is described. The separations were performed using mobile phases which consist of alcohol (methanol, ethanol or 2-propanol)/n-hexane in various proportions. The effect of structural features of the solutes along with the nature and concentration of alcohol in the mobile phase on the discrimination between the enantiomers was examined for different mobile phase compositions. The results suggest that not only the structure and concentration of alcohol in the mobile phase, but also the subtle structural differences in racemates can have a pronounced effect on enantiomeric separation and retention. Baseline separations were obtained for 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters carrying imidazole ring in addition to ester functional group in their structures. The alpha values of the resolved enantiomers of 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters were in the range of 1.49-1.62 while the R (s) values varied from 4.20 to 6.75 when methanol/n-hexane (70:30 v/v) was used as mobile phase.
Açıklama
Anahtar Kelimeler
HPLC, Enantiomer separation, Cellulose tris(3,5-dimethylphenyl carbamate), Chiralcel OD, 1-(2-Naphthyl)-1-ethanol ester derivatives
Kaynak
Chromatographia
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
75
Sayı
19-20
