Enantioseparation of Some New 1-(2-Naphthyl)-1-ethanol Ester Derivatives by HPLC on Chiralcel OD

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dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.contributor.authorKarakurt, A.
dc.contributor.authorSarac, S.
dc.contributor.authorDalkara, S.
dc.date.accessioned2024-08-04T20:58:38Z
dc.date.available2024-08-04T20:58:38Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe direct enantiomeric resolution of racemic 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters, 1-(naphthalene-2-yl)ethanol esters, and 1-(1-hydroxynaphthalene-2-yl)-2-(1H-imidazole-1-yl)ethanol on silica-based cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD) column is described. The separations were performed using mobile phases which consist of alcohol (methanol, ethanol or 2-propanol)/n-hexane in various proportions. The effect of structural features of the solutes along with the nature and concentration of alcohol in the mobile phase on the discrimination between the enantiomers was examined for different mobile phase compositions. The results suggest that not only the structure and concentration of alcohol in the mobile phase, but also the subtle structural differences in racemates can have a pronounced effect on enantiomeric separation and retention. Baseline separations were obtained for 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters carrying imidazole ring in addition to ester functional group in their structures. The alpha values of the resolved enantiomers of 2-(1H-imidazole-1-yl)-1-naphthalene-2-yl)ethanol esters were in the range of 1.49-1.62 while the R (s) values varied from 4.20 to 6.75 when methanol/n-hexane (70:30 v/v) was used as mobile phase.en_US
dc.description.sponsorshipHacettepe University Research Fund [05D 01 301 001]en_US
dc.description.sponsorshipThe authors thank the Hacettepe University Research Fund for financial support (Project number: 05D 01 301 001).en_US
dc.identifier.doi10.1007/s10337-012-2303-8
dc.identifier.endpage1197en_US
dc.identifier.issn0009-5893
dc.identifier.issue19-20en_US
dc.identifier.startpage1191en_US
dc.identifier.urihttps://doi.org/10.1007/s10337-012-2303-8
dc.identifier.urihttps://hdl.handle.net/11616/103046
dc.identifier.volume75en_US
dc.identifier.wosWOS:000309223800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofChromatographiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHPLCen_US
dc.subjectEnantiomer separationen_US
dc.subjectCellulose tris(3,5-dimethylphenyl carbamate)en_US
dc.subjectChiralcel ODen_US
dc.subject1-(2-Naphthyl)-1-ethanol ester derivativesen_US
dc.titleEnantioseparation of Some New 1-(2-Naphthyl)-1-ethanol Ester Derivatives by HPLC on Chiralcel ODen_US
dc.typeArticleen_US

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