Modulation of DMBA-induced biochemical changes by organoselenium compounds in blood of rats

Basit Öğe Kaydı
dc.authorscopusid7005334931
dc.authorscopusid23471088100
dc.authorscopusid6507504123
dc.authorscopusid7005138869
dc.authorscopusid7004914053
dc.contributor.authorOzdemir I.
dc.contributor.authorSelamoglu Z.
dc.contributor.authorAtes B.
dc.contributor.authorGok Y.
dc.contributor.authorYilmaz I.
dc.date.accessioned2024-08-04T19:59:22Z
dc.date.available2024-08-04T19:59:22Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe protective role of two synthetic organoselenium compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (SeI) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (SeII) was examined against the 7,12-dimethylbenz[a]anthracene (DMBA)-induced changes in biochemical parameters in blood of rats. Albino Winstar rats (150-200 g body wt) were treated with single dose of DMBA (50 mg/kg body wt) and organoselenium compounds (25 ?mol/kg) for 4 weeks at two days internal. Blood was taken from the anaesthetized rats ventricle from their hearts for biochemical analysis. Administration of DMBA resulted in elevation of urea, uric acid and creatinine levels as well as AST, ALT and LDH activities and decrease in levels of total proteins, albumin and globulin. SeI and SeII caused a significant (p<0.05) decrease in urea, uric acid and creatinine levels and alanine aminotransferase (ALT); aspartate aminotransferase; (AST) and lactate dehydrogenase (LDH) activities and significantly increased the levels of total protein and albumin (p<0.05). These organoselenium compounds are likely to be beneficial in human health.en_US
dc.identifier.endpage259en_US
dc.identifier.issn0301-1208
dc.identifier.issue4en_US
dc.identifier.pmid17970285en_US
dc.identifier.scopus2-s2.0-84924275288en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://hdl.handle.net/11616/90573
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Biochemistry and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject7, 12-dimethylbenz [a]anthracene or DMBAen_US
dc.subjectBiochemical parametersen_US
dc.subjectOrganoselenium compoundsen_US
dc.subjectOxidative stressen_US
dc.titleModulation of DMBA-induced biochemical changes by organoselenium compounds in blood of ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu