Aqueous humor adrenomedullin levels differ in patients with different types of glaucoma

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorEvereklioglu, C
dc.contributor.authorDoganay, S
dc.contributor.authorEr, H
dc.contributor.authorYurekli, M
dc.date.accessioned2024-08-04T20:12:23Z
dc.date.available2024-08-04T20:12:23Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Adrenomedullin is a multifunctional 52 amino acid large peptide. Recent studies have reported that it is expressed in the iris-ciliary body in the eye and that it decreases intraocular pressure (IOP) by increasing outflow facility via specific adrenomedullin receptors, suggesting a role for this peptide in controlling IOP. In the present study, we aimed to explore clinically the possible involvement of adrenomedullin in the pathophysiology of glaucoma. Methods: Reverse-phase high-performance liquid chromatography was used to determine the aqueous humor adrenomedullin levels in 41 patients (41 eyes) undergoing elective surgery for a variety of ocular diseases in the Research Hospital of Inonu University Medical Faculty between 1999 and 2000. The ocular diseases of the patients included primary open-angle glaucoma (POAG, n = 16), neovascular glaucoma (NG, n = 11). and cataract (n = 14). The study was an open trial with purposive sampling. Aqueous humor samples were taken by paracentesis. Mann-Whitney U-test was used in the statistical analysis and P < .05 was considered as significant. Results were expressed as mean +/- SE. Results: The mean age and sex distribution between groups were comparable. Mean adrenomedullin levels in patients with POAG (22.3 +/- 0.6 pmol/L) were significantly higher than those in patients with NG (5.6 +/- 0.2. pmol/L; P < .001) and cataract (11.9 +/- 0.5, pmol/L., P < .001). On the other hand, the mean aqueous humor adrenomedullin levels in patients with NG were significantly (P < .001) lower than those in cataract patients. Conclusions: This first clinical in vivo study on aqueous humor adrenomedullin levels showed that this peptide may be involved in the pathophysiology of glaucoma. Increased aqueous humor adrenomedullin levels in patients with POAG may indicate a compensatory defense response against increased IOP to slow the formation and progression of a vicious cycle, On the other hand, there may be deficient production of the peptide in patients with NG, or adrenomedullin-producing cells may be lost because of very high IOP during the course of the disease. The control of adrenomedullin levels in the eve might be a target that could be considered in the therapeutic strategies for glaucoma. Further studies in this respect are needed. (C) 2002 Japanese Ophthalmological Society.en_US
dc.identifier.doi10.1016/S0021-5155(01)00501-9
dc.identifier.endpage208en_US
dc.identifier.issn0021-5155
dc.identifier.issn1613-2246
dc.identifier.issue2en_US
dc.identifier.pmid12062228en_US
dc.identifier.scopus2-s2.0-0036228766en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1016/S0021-5155(01)00501-9
dc.identifier.urihttps://hdl.handle.net/11616/93395
dc.identifier.volume46en_US
dc.identifier.wosWOS:000174959300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJapanese Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectaqueous humoren_US
dc.subjectglaucomaen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectpathophysiologyen_US
dc.titleAqueous humor adrenomedullin levels differ in patients with different types of glaucomaen_US
dc.typeArticleen_US

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