Novel 3,6-Disubstituted 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines: Synthesis, Characterization, and Evaluation of Analgesic/Anti-inflammatory, Antioxidant Activities

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dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidAytac, Peri/AGY-9153-2022
dc.contributor.authorTozkoparan, Birsen
dc.contributor.authorAytac, Sevim Peri
dc.contributor.authorAktay, Goeknur
dc.date.accessioned2024-08-04T20:31:15Z
dc.date.available2024-08-04T20:31:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the synthesis of a new series of 3,6-disubstituted-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 1a-4c Compounds derived from 4-amino-3-substituted-1,2,4-triazole-5-thiones 1-4 is described. All of the synthesized compounds were screened for their possible analgesic / anti-inflammatory, antioxidant activities and gastric toxicity. The compound 2c was found to have both significant analgesic and consistent anti-inflammatory activity without inducing any gastric lesions along with minimal lipid peroxidation. A deep insight into the structures of the active compounds revealed that the compounds carrying an electron withdrawing group (a chloride or fluoride) on the phenyl ring at 6-position of the condensed heterocyclic derivatives exhibited noticeable higher activity.en_US
dc.identifier.doi10.1002/ardp.200800188
dc.identifier.endpage298en_US
dc.identifier.issn0365-6233
dc.identifier.issue5en_US
dc.identifier.pmid19415660en_US
dc.identifier.scopus2-s2.0-66349108764en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.200800188
dc.identifier.urihttps://hdl.handle.net/11616/94806
dc.identifier.volume342en_US
dc.identifier.wosWOS:000266509000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject4-Amino-3-mercapto-1,2,4-triazoleen_US
dc.subjectAnalgesic activityen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectAntioxidant activityen_US
dc.subject1,2,4-Triazolo[3,4-b][1,3,4]thiadiazinesen_US
dc.titleNovel 3,6-Disubstituted 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines: Synthesis, Characterization, and Evaluation of Analgesic/Anti-inflammatory, Antioxidant Activitiesen_US
dc.typeArticleen_US

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