Endometrial Na+, K+-ATPase pump function and vasopressin levels during hysteroscopic surgery in patients pretreated with GnRH agonist

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dc.authoridBuhur, Ali/0000-0003-1228-0962;
dc.authorwosidBuhur, Ali/GLQ-5966-2022
dc.authorwosidtaskin, omur/C-6864-2016
dc.contributor.authorTaskin, O
dc.contributor.authorBuhur, A
dc.contributor.authorBirincioglu, M
dc.contributor.authorBurak, F
dc.contributor.authorAtmaca, R
dc.contributor.authorYilmaz, I
dc.contributor.authorWheeler, JM
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description26th Annual Meeting of the American-Association-of-Gynecologic-Laparoscopists -- SEP 23-29, 1997 -- SEATTLE, WASHINGTONen_US
dc.description.abstractStudy Objective. To investigate the effects of gonadotropin-releasing hormone (GnRH) analog pretreatment on endometrial Na+, K+-adenosine triphosphatase (ATPase) pump function and peripheral blood vasopressin levels, and their role in fluid absorption and mechanisms of hyponatremia in patients undergoing hysteroscopic endometrial ablation. Design. Prospective, randomized, placebo-controlled study (Canadian Task Force classification I). Setting. University-affiliated hospital. Patients. Seventeen women with dysfunctional uterine bleeding. Intervention, Nine women received a GnRH analog and eight received saline approximately 6 to 8 weeks before hysteroscopic ablation by electrosurgery. Measurements and Main Results. Both before randomization and immediately before surgery, endometrial biopsy samples were obtained and numbered consecutively without patient identification. Operative hysteroscopy was performed with glycine 1.5% mixed with 2% alcohol. The amount of irrigant and irrigant deficit; blood levels of albumin and ethanol; hematocrit and hemoglobin; changes in sodium levels; and central venous pressure were compared. The Na+, K+-ATPase pump activity was significantly increased in the GnRH analog group compared with the saline group and correlated with decreased estradiol levels (0.4 +/- 0.08 vs 0.26 +/- 0.06 mu mol/min/ml). Vasopressin levels were significantly lower in the GnRH group (3.2 +/- 0.9 vs 7.6 +/- 1.7 mu mol/L). Mean volume of irrigant used and operating time were similar in both groups. Volume deficit, decrease in protein, and hematocrit were less in GnRH than in the saline group. Blood ethanol levels, decrease in sodium, and irrigant deficit were significantly lower in GnRH group. Conclusion. Pretreatment with GnRH analogs may prevent the adverse effects of estradiol on endometrial Na+, K+-ATPase and creates a protective mechanism against iatrogenic hyponatremia, which is more critical in women than men in case of absorption of irrigating fluid. Moreover, created hypoestrogenism may enhance Na+, K+-ATPase activity in brain as well as endometrium, thus decreasing women's susceptibility to hyponatremic complications and brain damage. Suppressed vasopressin levels may be protective against fluid absorption in GnRH analog-treated patients.en_US
dc.description.sponsorshipAmer Assoc Gynecol Laparoscopistsen_US
dc.identifier.doi10.1016/S1074-3804(98)80076-5
dc.identifier.endpage124en_US
dc.identifier.issn1074-3804
dc.identifier.issue2en_US
dc.identifier.pmid9564057en_US
dc.identifier.scopus2-s2.0-0031802516en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1016/S1074-3804(98)80076-5
dc.identifier.urihttps://hdl.handle.net/11616/93111
dc.identifier.volume5en_US
dc.identifier.wosWOS:000073847100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal Amer Assoc Gynecologic Laparoscopistsen_US
dc.relation.ispartofJournal of The American Association of Gynecologic Laparoscopistsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyponatremic Encephalopathyen_US
dc.subjectFemale Ratsen_US
dc.subjectResectionen_US
dc.subjectInhibitionen_US
dc.subjectAblationen_US
dc.subjectEstrogenen_US
dc.titleEndometrial Na+, K+-ATPase pump function and vasopressin levels during hysteroscopic surgery in patients pretreated with GnRH agonisten_US
dc.typeConference Objecten_US

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